A prospective study of telomere length and the risk of skin cancer.
A prospective study of telomere length and the risk of skin cancer.
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DOI：
10.1038/jid.2008.238
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发表时间：
2009-02
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影响因子：
--
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端粒长度在肿瘤发生中起关键作用。使用定量实时PCR，我们在护士健康研究（NHS）的巢式病例对照研究中前瞻性地测量了相对端粒长度：218例黑色素瘤病例，285例鳞状细胞癌（SCC）病例，300例基底细胞癌（BCC）病例和870例对照。我们观察到较短的端粒与痣数量减少（p=0.002）和黑色素瘤风险降低相关。端粒长度最短的第二和第一四分位数的女性与第一四分位数的女性相比，黑色素瘤的OR分别为0.54（95%CI，0.29-1.01）和0.59（95%CI，0.31-1.13）（P，趋势= 0.09）。端粒长度和SCC风险之间没有明显的趋势。相反，我们发现较短的端粒长度与基底细胞癌的风险增加有关。与第四个四分位数的女性相比，第一个四分位数的女性的OR为1.85（95%CI，0.94-3.62）（P，趋势=0.09）。观察到的相反关联应谨慎解释，需要进一步研究来证实这些可能的关联。
Telomere length plays a critical role in tumorigenesis. Using quantitative real-time PCR, we prospectively measured relative telomere length in a nested case-control study within the Nurses’ Health Study (NHS): 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 controls. We observed that shorter telomeres were associated with a decreased number of moles (p=0.002) and a decreased risk of melanoma. Women in the second and first quartiles, those with the shortest telomere length, had an OR for melanoma of 0.54 (95%CI, 0.29-1.01) and 0.59 (95% CI, 0.31-1.13), respectively, compared with those in the fourth quartile (P, trend = 0.09). There was no clear trend between telomere length and SCC risk. In contrast, we found that shorter telomere length was associated with an increased risk of BCC. Compared with those in the fourth quartile, women in the first quartile had an OR of 1.85 (95%CI, 0.94-3.62) (P, trend =0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations.
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影响因子：
5
作者：
BAIN, C;COLDITZ, GA;SPEIZER, FE
通讯作者：
SPEIZER, FE
Naevi中的细胞衰老和黑色素瘤中的永生化：P16的作用？
影响因子：
8.8
作者：
Gray-Schopfer, V C;Cheong, S C;Chong, H;Chow, J;Moss, T;Abdel-Malek, Z A;Marais, R;Wynford-Thomas, D;Bennett, D C
通讯作者：
Bennett, D C
DOI：
10.1098/rstb.2003.1370
发表时间：
2004-01-29
影响因子：
6.3
作者：
Chan, SRWL;Blackburn, EH
通讯作者：
Blackburn, EH
影响因子：
3.8
作者：
McGrath, Monica;Wong, Jason Y. Y.;De Vivo, Immaculata
通讯作者：
De Vivo, Immaculata
影响因子：
3.8
作者：
Bataille, Veronique;Kato, Bernet S.;Spector, Tim D.
通讯作者：
Spector, Tim D.