Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts.
Higher motor cortical excitability linked to greater cognitive dysfunction in Alzheimer's disease: results from two independent cohorts.
复制标题
DOI：
10.1016/j.neurobiolaging.2021.06.007
复制
发表时间：
2021-12
影响因子：
4.2
通讯作者：
Fried PJ
中科院分区：
文献类型：
--
作者：
Zadey S;Buss SS;McDonald K;Press DZ;Pascual-Leone A;Fried PJ
先前的研究已经报道了阿尔茨海默病（AD）患者的皮质兴奋性增加，但研究结果并不一致，并且兴奋性与痴呆严重程度的关系仍然不完全清楚。本研究的目的是探讨经颅磁刺激（TMS）测量运动皮层兴奋性和AD认知测量之间的关联。一项回顾性横断面分析在两个独立的AD参与者样本（发现队列，n=22和更大的验证队列，n=129）和认知正常成人对照队列（n=26）中测试了静息运动阈值（RMT）和阿尔茨海默病评估量表-认知子量表（ADAS-Cog）之间的关系。在发现-AD队列中，RMT与ADAS-Cog相关（n=22，β=-0.70，p<0.001），但在对照队列中不相关（n=26，β=-0.13，p=0.513）。这种关系在验证-AD队列中得到了证实（n=129，β=-0.35，p <0.001）。RMT可作为AD患者进行性整体认知功能障碍的一个有用的神经生理学标志物。未来的转化研究应该集中在RMT预测和跟踪个人衰老的病理生理轨迹的潜力。
Prior studies have reported increased cortical excitability in people with Alzheimer’s disease (AD), but findings have been inconsistent, and how excitability relates to dementia severity remains incompletely understood. The objective of this study was to investigate the association between a transcranial magnetic stimulation (TMS) measure of motor cortical excitability and measures of cognition in AD. A retrospective cross-sectional analysis tested the relationship between resting motor threshold (RMT) and the Alzheimer’s Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) across two independent samples of AD participants (a discovery cohort, n=22 and a larger validation cohort, n=129) and a control cohort of cognitively normal adults (n=26). RMT was correlated with ADAS-Cog in the discovery-AD cohort (n=22, β=−.70, p<0.001) but not in the control cohort (n=26, β=−0.13, p=0.513). This relationship was confirmed in the validation-AD cohort (n=129, β=−.35, p <0.001). RMT can be a useful neurophysiological marker of progressive global cognitive dysfunction in AD. Future translational research should focus on the potential of RMT to predict and track individual pathophysiological trajectories of aging.
登录
查看更多内容
影响因子：
4.2
作者：
Buss SS;Press DZ;McDonald K;Kitchener E;O'Connor M;Donohoe K;Shafi MM;Pascual-Leone A;Fried PJ
通讯作者：
Fried PJ
影响因子：
3.2
作者：
Crane, Paul K.;Carle, Adam;Gibbons, Laura E.;Insel, Philip;Mackin, R. Scott;Gross, Alden;Jones, Richard N.;Mukherjee, Shubhabrata;Curtis, S. McKay;Harvey, Danielle;Weiner, Michael;Mungas, Dan
通讯作者：
Mungas, Dan
影响因子：
3.9
作者：
Freitas, Catarina;Mondragon-Llorca, Helena;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
3.7
作者：
Cavaleri R;Schabrun SM;Chipchase LS
通讯作者：
Chipchase LS
影响因子：
4.8
作者：
Ferreri, Florinda;Vecchio, Fabrizio;Di Lazzaro, Vincenzo
通讯作者：
Di Lazzaro, Vincenzo