The rotavirus vaccine development pipeline.
The rotavirus vaccine development pipeline.
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DOI：
10.1016/j.vaccine.2017.03.076
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发表时间：
2019-11-28
期刊：
影响因子：
5.5
通讯作者：
Steele AD
中科院分区：
文献类型：
--
作者：
Kirkwood CD;Ma LF;Carey ME;Steele AD
轮状病毒病是全球5岁以下儿童死亡和发病的主要原因。这两种全球使用的口服轮状病毒疫苗在引入发达国家和发展中国家后，其有效性迅速显现，轮状病毒相关死亡率和住院率显著降低。然而，在发展中国家，疫苗的有效性和影响降低，因为那里的负担和死亡率最高。新的轮状病毒疫苗，包括口服轮状病毒活候选疫苗和非复制方法，仍在开发中，主要目的是改善轮状病毒疫苗的全球供应和地方实施，并提高疫苗在发展中国家的有效性。本综述概述了发展中国家生产商正在开发的新型轮状病毒疫苗，并提供了继续探索新候选疫苗的理由。它描述了新的口服轮状病毒活疫苗候选者以及沿着发展的非复制型轮状病毒疫苗。
Rotavirus disease is a leading global cause of mortality and morbidity in children under 5 years of age. The effectiveness of the two globally used oral rotavirus vaccines quickly became apparent when introduced into both developed and developing countries, with significant reductions in rotavirus-associated mortality and hospitalizations. However, the effectiveness and impact of the vaccines is reduced in developing country settings, where the burden and mortality is highest. New rotavirus vaccines, including live oral rotavirus candidates and non-replicating approaches continue to be developed, with the major aim to improve the global supply of rotavirus vaccines and for local implementation, and to improve vaccine effectiveness in developing settings. This review provides an overview of the new rotavirus vaccines in development by developing country manufacturers and provides a rationale why newer candidates continue to be explored. It describes the new live oral rotavirus vaccine candidates as well as the non-replicating rotavirus vaccines that are furthest along in development.
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