The Adipocyte and Adaptive Immunity.
The Adipocyte and Adaptive Immunity.
复制标题
脂肪细胞和适应性免疫
DOI：
10.3389/fimmu.2020.593058
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发表时间：
2020
影响因子：
7.3
通讯作者：
Deng T
中科院分区：
文献类型：
--
作者：
Song J;Deng T
脂肪细胞不仅具有能量储存和内分泌功能，还具有免疫功能。脂肪细胞参与适应性免疫介导多种慢性炎症性疾病和自身免疫性综合征的病理过程。适应性免疫反应包括T细胞介导的细胞免疫和B细胞介导的体液免疫。肥胖脂肪细胞过度表达MHC II类分子和共刺激因子，作为抗原呈递细胞（APCs），促进CD4+ T细胞的活化。此外，脂肪细胞分泌的各种脂肪因子调节T细胞的增殖和分化。脂肪因子还参与B细胞的产生、发育、活化和抗体的产生。因此，脂肪细胞在B细胞介导的适应性免疫中起着重要作用。本文从T细胞和B细胞的角度阐述了脂肪细胞参与适应性免疫的机制，并讨论了它们在多种疾病发病机制中的作用。
Not only do Adipocytes have energy storage and endocrine functions, but they also play an immunological role. Adipocytes are involved in adaptive immunity to mediate the pathological processes of a variety of chronic inflammatory diseases and autoimmune syndromes. The adaptive immune response consists of T cell-mediated cellular immunity and B cell-mediated humoral immunity. Obese adipocytes overexpress MHC class II molecules and costimulators to act as antigen-presenting cells (APCs) and promote the activation of CD4+ T cells. In addition, various adipokines secreted by adipocytes regulate the proliferation and differentiation of T cells. Adipokines are also involved in B cell generation, development, activation, and antibody production. Therefore, adipocytes play an important role in B cell-mediated adaptive immunity. This review describes how adipocytes participate in adaptive immunity from the perspective of T cells and B cells, and discusses their role in the pathogenesis of various diseases.
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影响因子：
29
作者：
Deng T;Lyon CJ;Minze LJ;Lin J;Zou J;Liu JZ;Ren Y;Yin Z;Hamilton DJ;Reardon PR;Sherman V;Wang HY;Phillips KJ;Webb P;Wong ST;Wang RF;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
16.6
作者：
Deng T;Liu J;Deng Y;Minze L;Xiao X;Wright V;Yu R;Li XC;Blaszczak A;Bergin S;DiSilvestro D;Judd R;Bradley D;Caligiuri M;Lyon CJ;Hsueh WA
通讯作者：
Hsueh WA
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
T细胞共刺激和共抑制的分子机制。
DOI：
10.1038/nri3405
发表时间：
2013-04
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.1
作者：
Agrawal, Sudhanshu;Gupta, Sudhir
通讯作者：
Gupta, Sudhir