Epithelial-mesenchymal transition in tissue repair and fibrosis.
Epithelial-mesenchymal transition in tissue repair and fibrosis.
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DOI：
10.1007/s00441-016-2464-0
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发表时间：
2016-09
影响因子：
3.6
通讯作者：
Tomic-Canic, Marjana
中科院分区：
文献类型：
--
作者：
Stone, Rivka C.;Pastar, Irena;Ojeh, Nkemcho;Chen, Vivien;Liu, Sophia;Garzon, Karen I.;Tomic-Canic, Marjana
上皮-间质转化（EMT）描述了静止上皮细胞经历表型变化的整体过程，包括细胞间粘附和顶端-基底极性的丧失，并获得赋予迁移能力的间质特征。 EMT 及其相反的 MET（间充质到上皮细胞的转变）是许多生理过程的组成部分，因此受到许多分子调节因子的紧密协调。多种证据表明 EMT 是皮肤伤口愈合的一个组成部分，在此期间，原本静止的角质形成细胞（常驻皮肤上皮细胞）迁移穿过伤口床以恢复表皮屏障。此外，EMT还在疤痕和纤维化的发展中发挥着作用，因为产生基质的肌成纤维细胞是由上皮谱系细胞响应损伤而产生的，但在病理上是持续的，而不是经历MET或细胞凋亡。在这篇综述中，我们总结了EMT在组织器官的生理修复和病理纤维化中的作用。我们的结论是，进一步研究 EMT 对纤维化伤口修复受损的贡献可能会确定 EMT 信号成分作为许多组织愈合受损的常见治疗靶点。
Epithelial-mesenchymal transition (EMT) describes the global process by which stationary epithelial cells undergo phenotypic changes, including loss of cell-cell adhesion and apical-basal polarity, and acquire mesenchymal characteristics which confer migratory capacity. EMT and its converse, MET (mesenchymal-to-epithelial transition), are integral stages of many physiologic processes, and as such are tightly coordinated by a host of molecular regulators. Converging lines of evidence have identified EMT as a component of cutaneous wound healing, during which otherwise stationary keratinocytes - the resident skin epithelial cells - migrate across the wound bed to restore the epidermal barrier. Moreover, EMT also plays a role in the development of scarring and fibrosis, as the matrix-producing myofibroblast arises from cells of epithelial lineage in response to injury but is pathologically sustained instead of undergoing MET or apoptosis. In this review, we summarize the role of EMT in physiologic repair and pathologic fibrosis of tissues and organs. We conclude that further investigation into the contribution of EMT to the impaired repair of fibrotic wounds may identify components of EMT signaling as common therapeutic targets for impaired healing in many tissues.
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影响因子：
17.1
作者：
Eming SA;Martin P;Tomic-Canic M
通讯作者：
Tomic-Canic M
影响因子：
5.2
作者：
Direkze, NC;Forbes, SJ;Wright, NA
通讯作者：
Wright, NA
DOI：
10.1073/pnas.062010399
发表时间：
2002-03-19
影响因子：
11.1
作者：
Dong, CM;Zhu, SK;Goldschmidt-Clermont, PJ
通讯作者：
Goldschmidt-Clermont, PJ
影响因子：
3.3
作者：
Arnoux, Valerie;Nassour, Mayssaa;Savagner, Pierre
通讯作者：
Savagner, Pierre
影响因子：
2.7
作者：
Camenisch, TD;Molin, DGM;Klewer, SE
通讯作者：
Klewer, SE