Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.
Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.
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组蛋白 4 赖氨酸 5/12 乙酰化使 Pristionchus 口腔形态具有发育可塑性。
DOI：
10.1038/s41467-023-37734-z
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发表时间：
2023-04-13
影响因子：
16.6
通讯作者：
Sommer, Ralf J. J.
中科院分区：
文献类型：
--
作者：
Werner, Michael S. S.;Loschko, Tobias;King, Thomas;Reich, Shelley;Theska, Tobias;Franz-Wachtel, Mirita;Macek, Boris;Sommer, Ralf J. J.
发育可以被改变以使表型与环境相匹配，并且指导这种替代表型的遗传机制开始被阐明。然而，支配环境敏感性与不变发展的规则，以及潜在的表观遗传记忆，仍然未知。在这里，我们表明，可塑性的线虫口的形式是由组蛋白4赖氨酸5和12乙酰化（H4 K5/12 ac）。在早期幼虫阶段的乙酰化提供了一个允许的染色质状态，这是容易诱导的环境敏感性的关键窗口期间。随着发育的进行，去乙酰化作用关闭了开关基因的表达，从而结束了关键期。抑制去乙酰化酶导致固定的先前的发展轨迹，表明组蛋白的修改在青少年可以携带环境信息的成年人。最后，我们提供的证据表明，这一规定是来自一个古老的机制许可证的发展速度。总之，我们的研究结果表明，H4 K5/12 ac使发育可塑性的表观遗传调控，可以存储和删除乙酰化和脱乙酰化，分别。发育可塑性允许生物体将性状与其环境相匹配，然而，很少有已知的分子机制支持这种可塑性。在这里，作者表明，在成年Pristionchus线虫的喂养变形设置在一个关键窗口在青少年和确定H4 K5/12 ac作为环境信息载体。
Development can be altered to match phenotypes with the environment, and the genetic mechanisms that direct such alternative phenotypes are beginning to be elucidated. Yet, the rules that govern environmental sensitivity vs. invariant development, and potential epigenetic memory, remain unknown. Here, we show that plasticity of nematode mouth forms is determined by histone 4 lysine 5 and 12 acetylation (H4K5/12ac). Acetylation in early larval stages provides a permissive chromatin state, which is susceptible to induction during the critical window of environmental sensitivity. As development proceeds deacetylation shuts off switch gene expression to end the critical period. Inhibiting deacetylase enzymes leads to fixation of prior developmental trajectories, demonstrating that histone modifications in juveniles can carry environmental information to adults. Finally, we provide evidence that this regulation was derived from an ancient mechanism of licensing developmental speed. Altogether, our results show that H4K5/12ac enables epigenetic regulation of developmental plasticity that can be stored and erased by acetylation and deacetylation, respectively. Developmental plasticity allows organisms to match traits to their environment, however, there are few known molecular mechanisms underlying such plasticity. Here, the authors show that feeding morphs in adult Pristionchus nematodes are set during a critical window in juveniles and identify H4K5/12ac as the environmental information carrier.
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影响因子：
64.8
作者：
Heintzman, Nathaniel D.;Hon, Gary C.;Hawkins, R. David;Kheradpour, Pouya;Stark, Alexander;Harp, Lindsey F.;Ye, Zhen;Lee, Leonard K.;Stuart, Rhona K.;Ching, Christina W.;Ching, Keith A.;Antosiewicz-Bourget, Jessica E.;Liu, Hui;Zhang, Xinmin;Green, Roland D.;Lobanenkov, Victor V.;Stewart, Ron;Thomson, James A.;Crawford, Gregory E.;Kellis, Manolis;Ren, Bing
通讯作者：
Ren, Bing
影响因子：
14.8
作者：
Bradner, James E.;West, Nathan;Grachan, Melissa L.;Greenberg, Edward F.;Haggarty, Stephen J.;Warnow, Tandy;Mazitschek, Ralph
通讯作者：
Mazitschek, Ralph
影响因子：
4.4
作者：
Cox, Juergen;Neuhauser, Nadin;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
8.8
作者：
Behera, Vivek;Stonestrom, Aaron J.;Blobel, Gerd A.
通讯作者：
Blobel, Gerd A.
影响因子：
5.3
作者：
Baroncelli, Laura;Scali, Manuela;Sale, Alessandro
通讯作者：
Sale, Alessandro