Wake-like skin patterning and neural activity during octopus sleep.
Wake-like skin patterning and neural activity during octopus sleep.
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DOI：
10.1038/s41586-023-06203-4
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发表时间：
2023-07
期刊：
影响因子：
64.8
通讯作者：
Reiter, Sam
中科院分区：
文献类型：
--
作者：
Pophale, Aditi;Shimizu, Kazumichi;Mano, Tomoyuki;Iglesias, Teresa L.;Martin, Kerry;Hiroi, Makoto;Asada, Keishu;Andaluz, Paulette Garcia;Van Dinh, Thi Thu;Meshulam, Leenoy;Reiter, Sam
在睡眠时，许多脊椎动物群体至少在两个睡眠阶段之间交替：快速眼球运动和慢波睡眠，部分特征分别是醒着的和同步的大脑活动。在这里，我们描绘了章鱼睡眠的两个阶段的神经和行为相关性，章鱼是海洋无脊椎动物，大约在5.5亿 百万年前从脊椎动物进化而来(参考文献。)并独立进化出巨大的大脑和行为的复杂性。章鱼的“安静”睡眠被大约60-S的明显身体动作和皮肤图案和纹理的快速变化有节奏地打断。我们表明，这些发作是稳态调节的，快速可逆，并伴随着更高的唤醒阈值，代表着一个明显的“活跃”睡眠阶段。对活跃的睡眠皮肤模式的计算分析揭示了不同的动态，通过章鱼之间保存的一系列模式，这些模式与清醒时看到的模式非常相似。来自中央大脑的高密度电生理记录显示，活跃睡眠期间的局部场电位(LFP)活动类似于清醒时的活动。LFP的活动因大脑区域而异，在活跃的睡眠中，最强的活动出现在上额叶和垂直叶，在解剖学上与学习和记忆功能相关的区域。在安静的睡眠中，这些区域相对安静，但产生的LFP振荡在频率和持续时间上类似于哺乳动物的睡眠纺锤波。章鱼与脊椎动物的相似性范围表明，章鱼两阶段睡眠的某些方面可能代表了复杂认知的汇聚特征。章鱼有一个明显的活跃睡眠阶段，行为和神经关联类似于脊椎动物的快速眼动睡眠，这可能代表了复杂认知的收敛特征。
While sleeping, many vertebrate groups alternate between at least two sleep stages: rapid eye movement and slow wave sleep, in part characterized by wake-like and synchronous brain activity, respectively. Here we delineate neural and behavioural correlates of two stages of sleep in octopuses, marine invertebrates that evolutionarily diverged from vertebrates roughly 550 million years ago (ref. ) and have independently evolved large brains and behavioural sophistication. ‘Quiet’ sleep in octopuses is rhythmically interrupted by approximately 60-s bouts of pronounced body movements and rapid changes in skin patterning and texture. We show that these bouts are homeostatically regulated, rapidly reversible and come with increased arousal threshold, representing a distinct ‘active’ sleep stage. Computational analysis of active sleep skin patterning reveals diverse dynamics through a set of patterns conserved across octopuses and strongly resembling those seen while awake. High-density electrophysiological recordings from the central brain reveal that the local field potential (LFP) activity during active sleep resembles that of waking. LFP activity differs across brain regions, with the strongest activity during active sleep seen in the superior frontal and vertical lobes, anatomically connected regions associated with learning and memory function. During quiet sleep, these regions are relatively silent but generate LFP oscillations resembling mammalian sleep spindles in frequency and duration. The range of similarities with vertebrates indicates that aspects of two-stage sleep in octopuses may represent convergent features of complex cognition. Octopuses possess a distinct active sleep stage, with behavioural and neural correlates resembling vertebrate REM sleep, which may represent convergent features of complex cognition.
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