Intracellular Mechanisms of Antidepressant Drug Action
Intracellular Mechanisms of Antidepressant Drug Action
复制标题
抗抑郁药物作用的细胞内机制
DOI：
10.1080/hrp_8.4.161
复制
发表时间：
2000
影响因子：
3.8
通讯作者：
R. Shelton
中科院分区：
文献类型：
--
作者：
R. Shelton
&NA;抗抑郁药物对单胺类如去甲肾上腺素和血清素的作用已经描述了三十年。然而，最近的研究已经超越了细胞表面受体的转导级联和基因表达。抗抑郁药物治疗似乎共享参与激活腺苷酸环化酶-蛋白激酶A级联或抑制磷脂酶C-蛋白激酶C机制的几种机制。最终，这些效应联合收割机调节靶基因的表达。已知抗抑郁治疗可激活或抑制几种特定基因。糖皮质激素和盐皮质激素受体、脑源性神经营养因子及其受体trkB和前脑啡肽原的mRNA稳态水平增强，而促肾上腺皮质激素释放激素、c-fos、N-甲基-D-天冬氨酸受体亚单位和神经生长因子1A的mRNA稳态水平降低。鉴定差异表达基因的新分子遗传学方法将有助于开发全新一代抗抑郁药物治疗的靶点。
&NA; The action of antidepressant drugs on monoamines such as norepinephrine and serotonin has been described for three decades. However, more‐recent research has looked beyond cell surface receptors to transductional cascades and gene expression. Antidepressant drug therapies seem to share several mechanisms involved in either activating the adenylyl cyclase‐protein kinase A cascade or inhibiting the phospholipase C‐protein kinase C mechanisms. These effects, ultimately, combine to regulate the expression of target genes. Several specific genes are known to be activated or inhibited by antidepressant therapies. Steady‐state levels of mRNA for glucocorticoid and mineralocorticoid receptors, brain‐derived neurotrophic factor and its receptor trkB, and preproenkephalin are enhanced, whereas those for corticotropin‐releasing hormone, c‐fos,N‐methyl‐D‐aspartate receptor subunits, and nerve‐growth factor 1A are reduced. New molecular genetic methods for identifying differentially expressed genes will aid in the development of targets for wholly new generations of antidepressant drug therapies.
登录
查看更多内容
影响因子：
5
作者：
Y. Watanabe;E. Gould;D. Daniels;H. Cameron;B. McEwen
通讯作者：
Y. Watanabe;E. Gould;D. Daniels;H. Cameron;B. McEwen
DOI：
10.1146/annurev.pa.30.040190.003331
发表时间：
1990
影响因子：
12.5
作者：
L. Birnbaumer
通讯作者：
L. Birnbaumer
DOI：
--
发表时间：
1995-10
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
J. Chen;M. Rasenick
通讯作者：
J. Chen;M. Rasenick
影响因子：
--
作者：
P. Delgado;L. Price;H. Miller;R. Salomon;G. Aghajanian;G. Heninger;D. Charney
通讯作者：
P. Delgado;L. Price;H. Miller;R. Salomon;G. Aghajanian;G. Heninger;D. Charney
米安色林急性和慢性治疗后血清素受体敏感性。
DOI：
--
发表时间：
1982
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Blackshear,MA;Sanders-Bush,E
通讯作者：
Sanders-Bush,E