Significance of dynamic evolution of TNF-α, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis.
Significance of dynamic evolution of TNF-α, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis.
复制标题
新生儿坏死性小肠结肠炎中TNF-α，IL-6和肠道脂肪酸结合蛋白水平的动态演化的重要性。
DOI：
10.3892/etm.2017.5532
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发表时间：
2018-03
影响因子：
2.7
通讯作者：
Sheng L
中科院分区：
文献类型：
--
作者：
Li Z;Sheng L
目的探讨新生儿坏死性小肠结肠炎(NEC)患儿血清肿瘤坏死因子-α、白介素6(IL-6)和肠道脂肪酸结合蛋白(I-α)水平的动态变化及意义。共纳入45例NEC患儿、45例非NEC患儿和45例健康新生儿。配对日龄、体重、孕周、分娩方式后，用双抗体夹心法测定入院后6、24、72h血清肿瘤坏死因子-α、白介素6、胰岛素样生长因子结合蛋白水平，并分析其与预后的关系。NEC组和非NEC组血清肿瘤坏死因子-α和IL-6水平在24 h达高峰，72 h下降，两组各时间点比较差异无统计学意义(P>；0.05)，但均高于对照组(P<；0.05)。NEC组和非NEC组血清I-FABP水平在6h达高峰，NEC组在72h、非NEC组在24 h下降，NEC组各时间点均显著高于非NEC组，健康组最低，差异有统计学意义(P<；0.05)。NEC组存活40例，死亡5例(11.1%)，非NEC组存活43例，死亡2例(4.4%)。NEC组存活患儿与死亡患儿在不同时间的血清肿瘤坏死因子-α和IL-6水平差异无统计学意义(P>；0.05)，但存活患儿血清i-FABP水平在6h、24 h显著低于死亡患儿(P<；0.05)，72 h时差异无统计学意义(P>；0.05)。非NEC组存活儿与死亡儿在不同时间的血清肿瘤坏死因子-α、IL-6和i-FABP水平差异无统计学意义(P>；0.05)。血清i-FABP水平及其动态变化可能是NEC早期诊断和预后评估的重要指标。
To study the significance of dynamic evolution of serum tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and intestinal fatty acid-binding protein (I-FABP) levels in neonatal necrotizing enterocolitis (NEC). A total of 45 NEC child patients, 45 non-NEC child patients and 45 healthy newborns were enrolled. After the day age, weight, gestational week and delivery mode were matched, the serum TNF-α, IL-6 and I-FABP levels at 6, 24 and 72 h after admission were measured via ELISA method, and their correlations with prognosis were analyzed. The levels of serum TNF-α and IL-6 in NEC and non-NEC group reached the peak at 24 h and fell at 72 h; there were no differences in each time point between the two groups (P>0.05), but the levels of serum TNF-α and IL-6 were higher than those in the control group (P<0.05). The level of serum I-FABP in NEC and non-NEC group reached the peak at 6 h, and it fell at 72 h in NEC group and 24 h in non-NEC group; the level of I-FABP in each time point in NEC was significantly higher than that in non-NEC group, and the level was the lowest in healthy group; the differences were statistically significant (P<0.05). There were 40 cases of survival and 5 cases of death (11.1%) in NEC group, while there were 43 cases of survival and 2 cases of death (4.4%) in non-NEC group. There were no differences in serum TNF-α and IL-6 levels at different times between surviving child patients and dead child patients in NEC group (P>0.05), but the levels of serum I-FABP in surviving child patients at 6 h and 24 h were significantly lower than those in dead child patients (P<0.05), and there was no difference at 72 h (P>0.05). There were no differences in serum TNF-α, IL-6 and I-FABP levels at different times between surviving and dead child patients in non-NEC group (P>0.05). Serum I-FABP level and its dynamic evolution may be important indexes of early diagnosis and prognosis evaluation of NEC.
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影响因子：
4.1
作者：
Coufal S;Kokesova A;Tlaskalova-Hogenova H;Snajdauf J;Rygl M;Kverka M
通讯作者：
Kverka M
影响因子：
3.6
作者：
Young, Christopher;Sharma, Renu;Neu, Josef
通讯作者：
Neu, Josef
影响因子：
4.3
作者：
Yang, Qi;Zheng, Feng-Ping;Wu, Bin
通讯作者：
Wu, Bin
DOI：
10.1038/nrgastro.2016.119
发表时间：
2016-10
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Cahill CM;Zhu W;Oziolor E;Yang YJ;Tam B;Rajanala S;Rogers JT;Walker WA
通讯作者：
Walker WA