Physical activity during pregnancy and offspring neurodevelopment and IQ in the first 4 years of life.
Physical activity during pregnancy and offspring neurodevelopment and IQ in the first 4 years of life.
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DOI：
10.1371/journal.pone.0110050
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hallal PC
中科院分区：
文献类型：
--
作者：
Domingues MR;Matijasevich A;Barros AJ;Santos IS;Horta BL;Hallal PC
母亲在怀孕期间的体力活动可能会改变后代的智商和儿童时期的神经发育。属于出生队列的儿童在3、12、24和48个月大时接受随访。在出生时回顾性评估怀孕期间的体力活动。采用Battelle发育量表（12、24和48个月）评估神经发育，采用Weschler智力量表（48个月）评估智商。神经发育基于Battelles'（第90百分位数），并作为连续结局进行分析。IQ作为一个连续的结果进行分析。潜在混杂因素包括：家庭收入、母亲年龄、教育程度、肤色、生育次数和吸烟情况;新生儿：早产、性别和出生体重不足。从出生到48个月，样本量从4231减少到3792。粗略的分析表明，48个月大时，活跃女性的孩子智商略高（5分）。在12个月和24个月的Battelle的评分是较高的后代从积极的母亲。在控制混杂因素后，怀孕期间的体力活动与12个月智商的Battelle量表呈正相关，然而，在48个月时没有观察到相关性。怀孕期间的体力活动似乎不会损害儿童的神经发育，活跃母亲的儿童在12个月时表现更好。
Maternal physical activity during pregnancy could alter offspring's IQ and neurodevelopment in childhood. Children belonging to a birth cohort were followed at 3, 12, 24 and 48 months of age. Physical activity during pregnancy was assessed retrospectively at birth. Neurodevelopment was evaluated by Battelle's Development Inventory (12, 24 and 48 months) and IQ by the Weschler's Intelligence Scale (48 months). Neurodevelopment was based on Battelles' (90th percentile) and also analyzed as a continuous outcome. IQ was analyzed as a continuous outcome. Potential confounders were: family income, mother's age, schooling, skin color, number of previous births and smoking; and newborns': preterm birth, sex and low birth weight. From birth to 48 months, sample size decreased from 4231 to 3792. Crude analysis showed that IQ at 48 months was slightly higher (5 points) among children from active women. The Battelle's score at 12 and 24 months was higher among offspring from active mothers. After controlling for confounders, physical activity during pregnancy was positively associated to the Battelle's Inventory at 12 months IQ, however, at 48 months no association was observed. Physical activity during pregnancy does not seem to impair children's neurodevelopment and children from active mothers presented better performance at 12 months.
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影响因子：
13.6
作者：
Huisman, Martijn;Araya, Ricardo;Oldehinkel, Albertine J.
通讯作者：
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DOI：
10.1016/s0002-9378(98)70444-2
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4.5
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通讯作者：
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