Plasticity of Multidimensional Receptive Fields in Core Rat Auditory Cortex Directed by Sound Statistics.
Plasticity of Multidimensional Receptive Fields in Core Rat Auditory Cortex Directed by Sound Statistics.
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DOI：
10.1016/j.neuroscience.2021.04.028
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发表时间：
2021-07-15
期刊：
影响因子：
3.3
通讯作者：
Schreiner, Christoph E.
中科院分区：
文献类型：
--
作者：
Homma, Natsumi Y.;Atencio, Craig A.;Schreiner, Christoph E.
关键词：
感觉皮层神经元可以非线性地整合各种输入。这一非线性过程的结果可以通过多个感受野分量或滤波器来近似，以表征随后的刺激偏好。然而，多维滤波器的功能特性尚未得到很好的理解。在这里，我们使用最大信息维度分析估计每个神经元的两个频谱时间感受野（STRF）。我们比较了它们的时间和频谱调制特性，并确定了两个 STRF 在核心大鼠听觉皮层、初级听觉皮层 (A1) 和腹侧听觉皮层 (VAF) 中捕获的刺激信息。第一个 STRF 是这两个领域中占主导地位的声音特征检测器。与第一个 STRF 相比，第二个 STRF 更喜欢较低的调制，并且具有较少的尖峰信息。两个 STRF 联合捕获的信息大于单个 STRF 捕获的信息，反映了两个滤波器的非线性相互作用。 A1 中的信息增益更大。接下来我们确定声学环境如何影响这两个 STRF 的结构和关系。在发育过程中，大鼠暴露于中等水平的频谱时间调制噪声。噪声暴露强烈改变了两个皮质区域中第一个 STRF 的光谱时间偏好。 A1 中的噪声暴露降低了两个 STRF 之间的相互作用，但 VAF 中却没有。结果揭示了 A1 和 VAF 之间新的功能区别，表明 (i) A1 的两个 STRF 之间的相互作用比 VAF 更强，(ii) 在这两个领域中，噪声暴露会更强烈地减少第一个 STRF 中噪声中包含的调制参数表示，以及 (iii) 噪声暴露引起的可塑性会影响 A1 中滤波器相互作用的强度。总而言之，确定每个神经元的两个 STRF 可以增强对核心听觉皮层皮质信息处理和可塑性效应的理解。
Sensory cortical neurons can nonlinearly integrate a wide range of inputs. The outcome of this nonlinear process can be approximated by more than one receptive field component or filter to characterize the ensuing stimulus preference. The functional properties of multidimensional filters are, however, not well understood. Here we estimated two spectrotemporal receptive fields (STRFs) per neuron using maximally informative dimension analysis. We compared their temporal and spectral modulation properties and determined the stimulus information captured by the two STRFs in core rat auditory cortical fields, primary auditory cortex (A1) and ventral auditory field (VAF). The first STRF is a dominant, sound feature detector in both fields. The second STRF preferred lower modulations and had less spike information compared to the first STRF. The information jointly captured by the two STRFs was larger than that captured by the individual STRF, reflecting nonlinear interactions of two filters. This information gain was larger in A1. We next determined how the acoustic environment affects the structure and relationship of these two STRFs. Rats were exposed to moderate levels of spectrotemporally modulated noise during development. Noise exposure strongly altered the spectrotemporal preference of the first STRF in both cortical fields. The interaction between the two STRFs was reduced by noise exposure in A1 but not in VAF. The results reveal new functional distinctions between A1 and VAF indicating that (i) A1 has stronger interactions of the two STRFs than VAF, (ii) in both fields, noise exposure diminishes modulation parameter representation contained in the noise more strongly for the first STRF, and (iii) plasticity induced by noise exposure can affect the strength of filter interactions in A1. Taken together, ascertaining two STRFs per neuron enhances the understanding of cortical information processing and plasticity effects in core auditory cortex.
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影响因子：
16.2
作者：
Atencio, Craig A.;Sharpee, Tatyana O.;Schreiner, Christoph E.
通讯作者：
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