Developmental sensory experience balances cortical excitation and inhibition.
Developmental sensory experience balances cortical excitation and inhibition.
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作者：
在生命的早期，神经回路非常容易受到外界影响。初级听觉皮层（AI）的组织特别是在关键时期的声学经验，一个时代附近的出生后发展的开始，在整个皮层突触和网络是特别的塑料。这种新生儿对感觉输入模式的敏感性被认为是构建稳定和适当适应的听觉世界表征以及儿童获得语言技能所必需的。成熟大脑中突触组织的一个重要原则是兴奋和抑制之间的平衡，它控制着感受野结构和神经活动的时空流动，但人们不知道这种兴奋-抑制平衡是如何以及何时最初建立和校准的。在这里，我们使用全细胞记录，以确定在大鼠AI突触感受野的发展过程。我们发现，听力发作后，感觉诱发的兴奋性和抑制性反应同样强烈，虽然抑制刺激选择性较低，与兴奋不匹配。然而，在出生后发育的第三周，兴奋和抑制变得高度相关。模式化的感觉刺激驱动整个感受野的协调突触变化，迅速改善兴奋-抑制耦合，并防止进一步的刺激诱导的修改。因此，皮质突触感受野发育的速度是由皮质内抑制的渐进的、经验依赖的细化来设定的。
Early in life, neural circuits are highly susceptible to outside influences. The organization of primary auditory cortex (AI) in particular is governed by acoustic experience during the critical period, an epoch near the beginning of postnatal development throughout which cortical synapses and networks are especially plastic. This neonatal sensitivity to the pattern of sensory inputs is believed to be essential for constructing stable and adequately adapted representations of the auditory world and for the acquisition of language skills by children. One important principle of synaptic organization in mature brains is the balance between excitation and inhibition, which controls receptive field structure and spatiotemporal flow of neural activity, but it is unknown how and when this excitatory-inhibitory balance is initially established and calibrated. Here we used whole-cell recording to determine the processes underlying the development of synaptic receptive fields in rat AI. We found that, immediately after hearing onset, sensory-evoked excitatory and inhibitory responses were equally strong, although inhibition was less stimulus-selective and mismatched with excitation. However, during the third week of postnatal development, excitation and inhibition became highly correlated. Patterned sensory stimulation drove coordinated synaptic changes across receptive fields, rapidly improved excitatory-inhibitory coupling, and prevented further exposure-induced modifications. Thus the pace of cortical synaptic receptive field development is set by progressive, experience-dependent refinement of intracortical inhibition.
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影响因子：
64.8
作者：
Lin, Yingxi;Bloodgood, Brenda L.;Hauser, Jessica L.;Lapan, Ariya D.;Koon, Alex C.;Kim, Tae-Kyung;Hu, Linda S.;Malik, Athar N.;Greenberg, Michael E.
通讯作者：
Greenberg, Michael E.
影响因子：
16.2
作者：
Meliza, CD;Dan, Y
通讯作者：
Dan, Y
DOI：
10.1073/pnas.0701944104
发表时间：
2007-05-01
影响因子：
11.1
作者：
Kenet, T.;Froemke, R. C.;Merzenich, M. M.
通讯作者：
Merzenich, M. M.
影响因子：
64.8
作者：
Wehr, M;Zador, AM
通讯作者：
Zador, AM
影响因子：
2.5
作者：
Froemke, RC;Tsay, IA;Dan, Y
通讯作者：
Dan, Y