Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes.
Worksite-based intensive lifestyle therapy has profound cardiometabolic benefits in people with obesity and type 2 diabetes.
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DOI：
10.1016/j.cmet.2022.08.012
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发表时间：
2022-10-04
期刊：
影响因子：
29
通讯作者：
Klein, Samuel
中科院分区：
文献类型：
--
作者：
Yoshino, Mihoko;Yoshino, Jun;Smith, Gordon I.;Stein, Richard I.;Bittel, Adam J.;Bittel, Daniel C.;Reeds, Dominic N.;Sinacore, David R.;Cade, W. Todd;Patterson, Bruce W.;Cho, Kevin;Patti, Gary J.;Mittendorfer, Bettina;Klein, Samuel
生活方式疗法（能量限制和运动）是2型糖尿病（T2 D）患者治疗的基石，但难以实施。我们在肥胖和T2 D患者（17名女性和1名男性）中进行了一项为期8个月的随机对照试验，以确定强化生活方式治疗对心脏代谢功能的治疗效果和潜在机制。在工作场所进行强化生活方式治疗以提高依从性，并导致体重显著减轻（17%），以及体脂肪量、肝内甘油三酯含量、心肺适应性、肌肉力量、血糖控制、β细胞功能和多器官胰岛素敏感性的有益变化，这些变化与肌肉NAD+生物合成、沉默调节蛋白信号传导、和线粒体功能以及脂肪组织重塑。这些发现表明，在工作场所提供的强化生活方式治疗对T2 D患者具有深远的治疗临床和生理作用，这可能是由骨骼肌和脂肪组织生物学的特定改变介导的。Mihoko等人报告称，在工作场所提供的强化生活方式治疗可使肥胖和2型糖尿病患者的体重显著减轻，心肺功能和肌肉力量增加，并改善与T2 D发病机制相关的生理因素（β细胞功能、多器官胰岛素敏感性和骨骼肌/脂肪组织生物学
Lifestyle therapy (energy-restriction and exercise) is the cornerstone of therapy for people with type 2 diabetes (T2D) but is difficult to implement. We conducted an 8-month randomized controlled trial in persons with obesity and T2D (17 women and 1 man) to determine the therapeutic effects and potential mechanisms of intensive lifestyle therapy on cardiometabolic function. Intensive lifestyle therapy was conducted at the worksite to enhance compliance and resulted in marked (17%) weight loss, and beneficial changes in body fat mass, intrahepatic triglyceride content, cardiorespiratory fitness, muscle strength, glycemic control, β-cell function and multi-organ insulin sensitivity, which were associated with changes in muscle NAD+ biosynthesis, sirtuin signaling, and mitochondrial function and in adipose tissue remodeling. These findings demonstrate that intensive lifestyle therapy provided at the worksite has profound therapeutic clinical and physiological effects in people with T2D, that are likely mediated by specific alterations in skeletal muscle and adipose tissue biology. ⦁ Mihoko et al. report that intensive lifestyle therapy provided at the worksite causes marked weight loss, increased cardiorespiratory fitness and muscle strength, and improved physiological factors involved in the pathogenesis of T2D (β-cell function, multi-organ insulin sensitivity, and skeletal muscle/adipose tissue biology) in people with obesity and type 2 diabetes
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影响因子：
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