The combination of cardiorespiratory fitness and muscle strength, and mortality risk.
The combination of cardiorespiratory fitness and muscle strength, and mortality risk.
复制标题
心肺健康和肌肉力量以及死亡率风险的结合。
DOI：
10.1007/s10654-018-0384-x
复制
发表时间：
2018-10
影响因子：
13.6
通讯作者：
Brage S
中科院分区：
文献类型：
--
作者：
Kim Y;White T;Wijndaele K;Westgate K;Sharp SJ;Helge JW;Wareham NJ;Brage S
关于心肺功能（CRF）和手握力（GS）与一般成年人群死亡率的联合关系知之甚少。本研究的目的是比较CRF、GS及其组合的相对死亡风险。在UK Biobank中，一个年龄在40-69岁的> 50万成年人的前瞻性队列，通过次极量自行车测试测量CRF;使用手部测力计测量GS。该分析基于70，913名男性和女性的数据（5.7年随访期间832例全因死亡，177例心血管死亡和503例癌症死亡），这些患者提供了有效的CRF和GS数据，并且在基线时没有心脏病发作/卒中/癌症病史。与最低CRF类别相比，调整混杂因素和GS后，中等和最高CRF类别的全因死亡率风险比（HR）分别为0.76 [95%置信区间（CI）0.64-0.89]和0.65（95% CI 0.55-0.78）。校正混杂因素和CRF后，最高GS类别与最低GS类别相比，全因死亡率的HR为0.79（95% CI 0.66-0.95）。心血管疾病和癌症死亡率也有类似的结果。与最低CRF和GS的参考类别相比，最高CRF和GS组合的全因死亡率和心血管死亡率的HR分别为0.53（95% CI 0.39-0.72）和0.31（95% CI 0.14-0.67）：与癌症死亡率无显著相关性（HR 0.70; 95% CI 0.48-1.02）。CRF和GS均为死亡率的独立预测因子。改善CRF和肌肉力量，而不是单独两者之一，可能是降低全因和心血管死亡风险的最有效的行为策略。本文的在线版本（10.1007/s10654-018-0384-x）包含补充材料，可供授权用户使用。
Little is known about the combined associations of cardiorespiratory fitness (CRF) and hand grip strength (GS) with mortality in general adult populations. The purpose of this study was to compare the relative risk of mortality for CRF, GS, and their combination. In UK Biobank, a prospective cohort of > 0.5 million adults aged 40–69 years, CRF was measured through submaximal bike tests; GS was measured using a hand-dynamometer. This analysis is based on data from 70,913 men and women (832 all-cause, 177 cardiovascular and 503 cancer deaths over 5.7-year follow-up) who provided valid CRF and GS data, and with no history of heart attack/stroke/cancer at baseline. Compared with the lowest CRF category, the hazard ratio (HR) for all-cause mortality was 0.76 [95% confidence interval (CI) 0.64–0.89] and 0.65 (95% CI 0.55–0.78) for the middle and highest CRF categories, respectively, after adjustment for confounders and GS. The highest GS category had an HR of 0.79 (95% CI 0.66–0.95) for all-cause mortality compared with the lowest, after adjustment for confounders and CRF. Similar results were found for cardiovascular and cancer mortality. The HRs for the combination of highest CRF and GS were 0.53 (95% CI 0.39–0.72) for all-cause mortality and 0.31 (95% CI 0.14–0.67) for cardiovascular mortality, compared with the reference category of lowest CRF and GS: no significant association for cancer mortality (HR 0.70; 95% CI 0.48–1.02). CRF and GS are both independent predictors of mortality. Improving both CRF and muscle strength, as opposed to either of the two alone, may be the most effective behavioral strategy to reduce all-cause and cardiovascular mortality risk. The online version of this article (10.1007/s10654-018-0384-x) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
39.2
作者：
Crump C;Sundquist J;Winkleby MA;Sieh W;Sundquist K
通讯作者：
Sundquist K
DOI：
10.1097/00005768-200205000-00002
发表时间：
2002-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Katzmarzyk, PT;Craig, CL
通讯作者：
Craig, CL
DOI：
10.1136/bmj.h4543
发表时间：
2015-09-16
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Andersen K;Rasmussen F;Held C;Neovius M;Tynelius P;Sundström J
通讯作者：
Sundström J
影响因子：
24
作者：
Artero, Enrique G.;Lee, Duck-chul;Ruiz, Jonatan R.;Sui, Xuemei;Ortega, Francisco B.;Church, Timothy S.;Lavie, Carl J.;Castillo, Manuel J.;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
4.5
作者：
Ho, Suleen S.;Dhaliwal, Satvinder S.;Pal, Sebely
通讯作者：
Pal, Sebely