Perceptual and motor responses directly and indirectly mediate the effects of noxious stimuli on autonomic responses.
Perceptual and motor responses directly and indirectly mediate the effects of noxious stimuli on autonomic responses.
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知觉和运动反应直接和间接介导有害刺激对自主反应的影响
DOI：
10.1097/j.pain.0000000000001661
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发表时间：
2019
期刊：
影响因子：
7.4
通讯作者：
Ploner M
中科院分区：
文献类型：
--
作者：
Tiemann L;Hohn VD;Ta Dinh S;May ES;Nickel MM;Heitmann H;Ploner M
自主神经反应是疼痛的重要组成部分。它们通过调节体内平衡和为对有害刺激的保护性和恢复性反应提供资源来发挥其适应功能。为了适应和灵活，自主神经反应不仅由伤害性刺激特征决定，还可能由对伤害性刺激的知觉和运动反应决定。然而，目前尚不完全清楚有害刺激特征、知觉反应和运动反应如何相互作用来塑造自主神经反应。为了解决这个问题，我们收集了47名健康人类参与者对不同强度的短暂有害激光刺激的知觉、运动和自主神经的反应。多水平双路径中介分析表明，伤害性刺激转化为自主神经反应的中介是知觉反应，而不是运动反应。多水平三路径中介分析进一步指出，运动反应通过与知觉反应的密切联系间接地与自主反应有关。这些发现证实，自主神经反应不仅是对伤害性刺激的反射性反应，而且分别由知觉反应和运动反应直接和间接塑造。运动和感知过程对自主反应的这些影响可能允许将上下文过程整合到保护性和调节性自主反应中，帮助自适应和灵活地应对威胁。
Autonomic responses are an essential component of pain. They serve its adaptive function by regulating homeostasis and providing resources for protective and recuperative responses to noxious stimuli. To be adaptive and flexible, autonomic responses are not only determined by noxious stimulus characteristics, but likely also shaped by perceptual and motor responses to noxious stimuli. However, it is not fully known how noxious stimulus characteristics, perceptual responses, and motor responses interact in shaping autonomic responses. To address this question, we collected perceptual, motor, and autonomic responses to brief noxious laser stimuli of different intensities in 47 healthy human participants. Multilevel 2-path mediation analyses revealed that perceptual, but not motor responses mediated the translation of noxious stimuli into autonomic responses. Multilevel 3-path mediation analyses further specified that motor responses indirectly related to autonomic responses through their close association with perceptual responses. These findings confirm that autonomic responses are not only a reflexive reaction to noxious stimuli, but directly and indirectly shaped by perceptual and motor responses, respectively. These effects of motor and perceptual processes on autonomic responses likely allow for the integration of contextual processes into protective and regulatory autonomic responses, aiding adaptive and flexible coping with threat.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
疼痛的生物精神运动概念化：对研究和干预的影响
DOI：
--
发表时间：
2008
期刊：
The Clinical Journal of Pain
影响因子：
--
作者：
M. Sullivan
通讯作者：
M. Sullivan
疼痛和防御反应：结构方程模型揭示了对增加疼痛刺激的协调心理生理反应
影响因子：
7.4
作者：
G. Donaldson;C. Chapman;Yoshio Nakamura;D. Bradshaw;R. Jacobson;C. N. Chapman
通讯作者：
C. N. Chapman
影响因子：
4.6
作者：
May ES;Tiemann L;Schmidt P;Nickel MM;Wiedemann N;Dresel C;Sorg C;Ploner M
通讯作者：
Ploner M
影响因子：
3.4
作者：
Henrik Heitmann;E. S. May;L. Tiemann;P. Schmidt;Moritz M. Nickel;Son Ta Dinh;Vanessa D. Hohn;T. Tölle;M. Ploner
通讯作者：
Henrik Heitmann;E. S. May;L. Tiemann;P. Schmidt;Moritz M. Nickel;Son Ta Dinh;Vanessa D. Hohn;T. Tölle;M. Ploner