The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda.
The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda.
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DOI：
10.1371/journal.pone.0048671
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Stein DJ
中科院分区：
文献类型：
--
作者：
Akena D;Musisi S;Joska J;Stein DJ
艾滋病毒/艾滋病感染者（PLWHA）的重度抑郁症很常见，可能与许多因素有关，包括艾滋病相关的耻辱感，CD 4水平下降，机会性感染增加和社会人口变量。在撒哈拉以南非洲，艾滋病相关污名与艾滋病毒感染者/艾滋病患者重度抑郁症之间的关联程度尚未得到充分研究。本研究的目的是探讨重性抑郁症，艾滋病相关的耻辱，免疫状态和社会人口变量之间的关联，目的是提出建议，可以指导临床医生。我们评估了368例PLWHA的重度抑郁症，以及潜在的相关因素，包括艾滋病相关的耻辱感，CD 4水平，机会性感染的存在和社会人口学变量。抑郁症的患病率为17.4%，而7.9%的参与者有艾滋病相关的耻辱。在多变量分析中，重性抑郁障碍与艾滋病相关的耻辱感[OR = 1.65，CI（1.20-2.26）]、CD 4计数≥200 [OR 0.52 CI（0.27-0.99）]和年龄较小[0.95，CI（0.92-0.98）]显著相关。 由于重度抑郁症的高负担，以及与艾滋病相关的耻辱感，建议对这两种情况进行PLWHA的常规筛查。然而，需要更多的研究来了解这种联系。
Major depressive disorder in people living with HIV/AIDS (PLWHA) is common and may be associated with a number of factors, including AIDS-related stigma, decreased CD4 levels, increased opportunistic infections and sociodemographic variables. The extent to which AIDS-related stigma is associated with major depressive disorder among PLWHA has not been well studied in sub-Saharan Africa. The objective of this study was to examine the associations between major depressive disorder, AIDS-related stigma, immune status, and sociodemographic variables with the aim of making recommendations that can guide clinicians. We assessed 368 PLWHA for major depressive disorder, as well as for potentially associated factors, including AIDS-related stigma, CD4 levels, presence of opportunistic infections, and sociodemographic variables. The prevalence of major depressive disorder was 17.4%, while 7.9% of the participants had AIDS related stigma. At multivariable analysis, major depressive disorder was significantly associated with AIDS-related stigma [OR = 1.65, CI (1.20–2.26)], a CD4 count of ≥200 [OR 0.52 CI (0.27–0.99)], and being of younger age [0.95, CI (0.92–0.98). Due to the high burden of major depressive disorder, and its association with AIDS related stigma, routine screening of PLWHA for both conditions is recommended. However, more research is required to understand this association.
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影响因子：
3.6
作者：
Kalichman, SC;Simbayi, LC
通讯作者：
Simbayi, LC
DOI：
10.1097/qai.0b013e318160d53e
发表时间：
2008-03-01
影响因子：
3.6
作者：
Horberg, Michael Alan;Silverberg, Michael Jonah;Kovach, Drew Anthony
通讯作者：
Kovach, Drew Anthony
影响因子：
4.4
作者：
Kaharuza, Frank M.;Bunnell, Rebecca;Mermin, Jonathan
通讯作者：
Mermin, Jonathan
影响因子：
17.7
作者：
Leserman, J;Petitto, JM;Evans, DL
通讯作者：
Evans, DL
影响因子：
5.4
作者：
Bjelland, Ingvar;Krokstad, Steinar;Tambs, K.
通讯作者：
Tambs, K.