Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls.
Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls.
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作为预防偏头痛的运动：使用松弛和托吡酯作为对照的随机研究。
DOI：
10.1177/0333102411419681
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Linde M
中科院分区：
文献类型：
--
作者：
Varkey E;Cider A;Carlsson J;Linde M
目的：需要关于运动预防偏头痛的科学证据。因此，本研究旨在评估运动在预防偏头痛中的作用。 研究方法：在一项针对成人偏头痛患者的随机对照试验中，将每周锻炼三次，每次40分钟与根据记录的计划或每日使用托吡酯进行放松进行比较，托吡酯缓慢增加至个人的最高耐受剂量（最大200 mg/天）。治疗期持续3个月，评估偏头痛状态、生活质量、体力活动水平和摄氧量。主要疗效变量是治疗最后一个月与基线相比偏头痛发作频率的平均降低。 结果：91例患者被随机化并纳入意向治疗分析。主要疗效变量显示，运动组平均减少0.93（95%置信区间（CI）0.31-1.54）次发作，放松组平均减少0.83（95% CI 0.22-1.45）次发作，托吡酯组平均减少0.97（95% CI 0.36-1.58）次发作。两组间未观察到显著差异（p = 0.95）。 结论：运动可能是预防性治疗偏头痛的一种选择，对于那些不能从每日药物治疗中获益或不想服用每日药物的患者来说。
Aim: Scientific evidence regarding exercise in migraine prophylaxis is required. Therefore this study aimed to evaluate the effects of exercise in migraine prevention. Methods: In a randomized, controlled trial of adults with migraine, exercising for 40 minutes three times a week was compared to relaxation according to a recorded programme or daily topiramate use, which was slowly increased to the individual’s highest tolerable dose (maximum 200 mg/day). The treatment period lasted for 3 months, and migraine status, quality of life, level of physical activity, and oxygen uptake were evaluated. The primary efficacy variable was the mean reduction of the frequency of migraine attacks during the final month of treatment compared with the baseline. Results: Ninety-one patients were randomized and included in the intention-to-treat analysis. The primary efficacy variable showed a mean reduction of 0.93 (95% confidence interval (CI) 0.31–1.54) attacks in the exercise group, 0.83 (95% CI 0.22–1.45) attacks in the relaxation group, and 0.97 (95% CI 0.36–1.58) attacks in the topiramate group. No significant difference was observed between the groups (p = 0.95). Conclusion: Exercise may be an option for the prophylactic treatment of migraine in patients who do not benefit from or do not want to take daily medication.
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