Virulence Factors and Pathogenicity Mechanisms of Acinetobacter baumannii in Respiratory Infectious Diseases.
Virulence Factors and Pathogenicity Mechanisms of Acinetobacter baumannii in Respiratory Infectious Diseases.
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DOI：
10.3390/antibiotics12121749
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发表时间：
2023-12-18
影响因子：
4.8
通讯作者：
Zhou, Hua
中科院分区：
文献类型：
--
作者：
Yao, Yake;Chen, Qi;Zhou, Hua
关键词：
鲍曼不动杆菌（A.鲍曼不动杆菌）已成为引起医院和社区获得性感染，特别是呼吸机相关性肺炎的臭名昭著的病原体。这种机会致病菌被发现具有强大的基因组可塑性和许多毒力因子，促进其在感染过程中的成功。虽然A.鲍曼不动杆菌和肺上皮细胞的研究已被广泛，但其整个致病过程缺乏完整和具体的描述。本文就近年来国内外对铜绿假单胞菌的耐药性及毒力因子的研究进展作一综述。鲍曼不动杆菌，特别关注这种有害病原体在呼吸道感染性疾病中的致病机制。扩展了对A.鲍曼不动杆菌的发病机理将有助于开发基于免疫病理学或细胞内信号传导途径的有效疗法，以在感染期间消除这种有害病原体。
Acinetobacter baumannii (A. baumannii) has become a notorious pathogen causing nosocomial and community-acquired infections, especially ventilator-associated pneumonia. This opportunistic pathogen is found to possess powerful genomic plasticity and numerous virulence factors that facilitate its success in the infectious process. Although the interactions between A. baumannii and the pulmonary epitheliums have been extensively studied, a complete and specific description of its overall pathogenic process is lacking. In this review, we summarize the current knowledge of the antibiotic resistance and virulence factors of A. baumannii, specifically focusing on the pathogenic mechanisms of this detrimental pathogen in respiratory infectious diseases. An expansion of the knowledge regarding A. baumannii pathogenesis will contribute to the development of effective therapies based on immunopathology or intracellular signaling pathways to eliminate this harmful pathogen during infections.
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