Acinetobacter: an emerging pathogen with a versatile secretome.
Acinetobacter: an emerging pathogen with a versatile secretome.
复制标题
DOI：
10.1038/s41426-018-0030-4
复制
发表时间：
2018-03-21
影响因子：
13.2
通讯作者：
Attia AS
中科院分区：
文献类型：
--
作者：
Elhosseiny NM;Attia AS
鲍曼不动杆菌是一种臭名昭著的病原体，近年来已成为医疗保健领域的噩梦，因为它会引起严重的感染，并导致高发病率和死亡率。由于其具有对几乎所有可用抗生素产生耐药性的非凡能力，鲍曼不动杆菌目前被列为世界卫生组织开发新抗生素优先名单上的第一个病原体。鲍曼不动杆菌分泌的多种效应子代表了迄今为止在该细菌中发现的毒力库的很大一部分。因此，这些因子与负责将其挤出到细胞外环境的分泌机制一起，是对抗这种致命病原体所急需的新型疗法的关键靶标。在这篇综述中，我们对不动杆菌分泌系统的组织和监管方面进行了全面、最新的概述，特别强调了其多功能底物，这些底物可用于对抗这种难以捉摸的病原体引起的致命感染。
Acinetobacter baumannii is a notorious pathogen that has emerged as a healthcare nightmare in recent years because it causes serious infections that are associated with high morbidity and mortality rates. Due to its exceptional ability to acquire resistance to almost all available antibiotics, A. baumannii is currently ranked as the first pathogen on the World Health Organization’s priority list for the development of new antibiotics. The versatile range of effectors secreted by A. baumannii represents a large proportion of the virulence arsenal identified in this bacterium to date. Thus, these factors, together with the secretory machinery responsible for their extrusion into the extracellular milieu, are key targets for novel therapeutics that are greatly needed to combat this deadly pathogen. In this review, we provide a comprehensive, up-to-date overview of the organization and regulatory aspects of the Acinetobacter secretion systems, with a special emphasis on their versatile substrates that could be targeted to fight the deadly infections caused by this elusive pathogen.
登录
查看更多内容
影响因子：
4.4
作者：
Eijkelkamp BA;Stroeher UH;Hassan KA;Paulsen IT;Brown MH
通讯作者：
Brown MH
影响因子：
3.8
作者：
Bardbari, Ali Mohammadi;Arabestani, Mohammad Reza;Bagheri, Kamran Pooshang
通讯作者：
Bagheri, Kamran Pooshang
影响因子：
11.4
作者：
DENFERT, C;RYTER, A;PUGSLEY, AP
通讯作者：
PUGSLEY, AP
影响因子：
4.4
作者：
Eijkelkamp BA;Hassan KA;Paulsen IT;Brown MH
通讯作者：
Brown MH
影响因子：
3.7
作者：
Carruthers MD;Nicholson PA;Tracy EN;Munson RS Jr
通讯作者：
Munson RS Jr