Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke.
Connectivity alterations assessed by combining fMRI and MR-compatible hand robots in chronic stroke.
复制标题
通过结合 fMRI 和 MR 兼容的手动机器人来评估慢性中风的连接改变。
DOI：
10.1016/j.neuroimage.2009.03.007
复制
发表时间：
2009-08
期刊：
影响因子：
5.7
通讯作者：
Tzika, A. Aria
中科院分区：
文献类型：
--
作者：
Mintzopoulos, Dionyssios;Astrakas, Loukas G.;Khanicheh, Azadeh;Konstas, Angelos A.;Singhal, Aneesh;Moskowitz, Michael A.;Rosen, Bruce R.;Tzika, A. Aria
关键词：
本研究的目的是通过使用功能磁共振成像 (fMRI) 结合新型 MR 兼容手诱导机器人设备 (MR_CHIROD) 探测慢性中风患者运动相关区域之间的连接性，来研究运动系统的功能重组。我们评估了从健康志愿者和右手为主的患者获得的数据集，这些患者在≥6个月前首次发生左侧中风，并且右手有轻度至中度偏瘫。我们通过 3 T MR 系统上的通用自动校准部分并行采集 (GRAPPA) 算法使用并行成像来获取 T1 加权回波平面和流体衰减反转恢复 MR 图像和多级 fMRI 数据。参与者在 MR 扫描仪中使用 MR_CHIROD 执行运动任务时接受了功能磁共振成像 (fMRI)。使用动态因果模型评估初级运动皮层（M1）、辅助运动区（SMA）和小脑（Ce）网络之间有效连接的变化。相对于健康对照，中风患者表现出 M1 和 Ce 之间的内在神经耦合减少，这与 M1 与 Ce 连接功能失调一致。中风患者还表现出 SMA 与 M1 以及 SMA 与小脑的耦合增加，这表明 SMA 和 Ce 连接的变化可能会发生以补偿功能失调的 M1。结果首次证明，运动区域之间的连接改变可能有助于平衡慢性中风患者的功能异常 M1。通过功能磁共振成像和 MR_CHIROD 评估连接的变化将来可能会用于进一步阐明慢性中风患者功能恢复的神经网络可塑性。
The aim of this study was to investigate functional reorganization of motor systems by probing connectivity between motor related areas in chronic stroke patients using functional magnetic resonance imaging (fMRI) in conjunction with a novel MR-compatible hand-induced, robotic device (MR_CHIROD). We evaluated data sets obtained from healthy volunteers and right-hand-dominant patients with first-ever left-sided stroke ≥6 months prior and mild to moderate hemiparesis affecting the right hand. We acquired T1-weighted echo planar and fluid attenuation inversion recovery MR images and multi-level fMRI data using parallel imaging by means of the GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) algorithm on a 3 T MR system. Participants underwent fMRI while performing a motor task with the MR_CHIROD in the MR scanner. Changes in effective connectivity among a network of primary motor cortex (M1), supplementary motor area (SMA) and cerebellum (Ce) were assessed using dynamic causal modeling. Relative to healthy controls, stroke patients exhibited decreased intrinsic neural coupling between M1 and Ce, which was consistent with a dysfunctional M1 to Ce connection. Stroke patients also showed increased SMA to M1 and SMA to cerebellum coupling, suggesting that changes in SMA and Ce connectivity may occur to compensate for a dysfunctional M1. The results demonstrate for the first time that connectivity alterations between motor areas may help counterbalance a functionally abnormal M1 in chronic stroke patients. Assessing changes in connectivity by means of fMRI and MR_CHIROD might be used in the future to further elucidate the neural network plasticity that underlies functional recovery in chronic stroke patients.
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影响因子：
4.8
作者：
Cramer, SC;Weisskoff, RM;Rosen, BR
通讯作者：
Rosen, BR
影响因子：
4.7
作者：
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通讯作者：
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作者：
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Rosen, BR
影响因子：
158.5
作者：
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通讯作者：
Dobkin, BH
DOI：
10.1016/j.apmr.2003.11.028
发表时间：
2004-07-01
影响因子：
4.3
作者：
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通讯作者：
Hogan, N