Fast odour dynamics are encoded in the olfactory system and guide behaviour.
Fast odour dynamics are encoded in the olfactory system and guide behaviour.
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DOI：
10.1038/s41586-021-03514-2
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发表时间：
2021-05
期刊：
影响因子：
64.8
通讯作者：
Schaefer AT
中科院分区：
文献类型：
--
作者：
Ackels T;Erskine A;Dasgupta D;Marin AC;Warner TPA;Tootoonian S;Fukunaga I;Harris JJ;Schaefer AT
气味在湍流羽流中传输，导致快速的浓度波动，其中包含有关嗅觉场景的丰富信息，例如气味源的组成和位置。然而，哺乳动物的嗅觉系统是否能够利用潜在的时间结构来提取有关环境的信息仍然是未知的。在这里，我们表明，10毫秒的气味脉冲模式导致嗅觉受体神经元的不同反应。在操作性条件反射实验中，小鼠辨别频率高达40 Hz的快速波动气味的时间相关性。在成像和电生理记录中，这种相关性信息可以很容易地从僧帽细胞和簇状细胞的活动中提取出来，这些细胞是嗅球的输出。此外，我们表明，气味浓度的时间相关性可靠地预测气味是否出现在复杂的气流自然环境中的相同或不同的来源。训练老鼠完成这些任务，并用不同频率的合成相关刺激进行探测，这表明老鼠确实可以利用气味的时间结构来提取有关空间的信息。因此，我们的工作表明，哺乳动物的嗅觉系统有机会获得出乎意料的快速的气味刺激的时间特征。这反过来又赋予动物克服关键行为挑战的能力，如气味源分离，图形-背景隔离和气味定位，通过提取有关空间的信息，从时间气味动态。
Odours are transported in turbulent plumes resulting in rapid concentration fluctuations that contain rich information about the olfactory scenery, such as odour source composition and location. Yet whether the mammalian olfactory system has access to the underlying temporal structure to extract information about the environment remains unknown. Here, we show that 10 ms odour pulse patterns result in distinct responses in olfactory receptor neurons. In operant conditioning experiments mice discriminated temporal correlations of rapidly fluctuating odours at frequencies of up to 40 Hz. In imaging and electrophysiological recordings, such correlation information could be readily extracted from the activity of mitral and tufted cells, the output of the olfactory bulb. Furthermore, we show that temporal correlation of odour concentrations reliably predicts whether odorants emerge from the same or different sources in naturalistic environments with complex airflow. Training mice on such tasks and probing with synthetic correlated stimuli at different frequencies suggests that mice can indeed use the temporal structure of odours to extract information about space. Our work thus demonstrates that the mammalian olfactory system has access to unexpectedly fast temporal features in odour stimuli. This in turn endows animals with the capacity to overcome key behavioural challenges such as odour source separation, figure-ground segregation and odour localisation, by extracting information about space from temporal odour dynamics.
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影响因子：
16.2
作者：
Jordan R;Fukunaga I;Kollo M;Schaefer AT
通讯作者：
Schaefer AT
影响因子：
16.2
作者：
Abraham NM;Egger V;Shimshek DR;Renden R;Fukunaga I;Sprengel R;Seeburg PH;Klugmann M;Margrie TW;Schaefer AT;Kuner T
通讯作者：
Kuner T
影响因子：
25
作者：
Haddad, Rafi;Lanjuin, Anne;Madisen, Linda;Zeng, Hongkui;Murthy, Venkatesh N.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
影响因子：
16.2
作者：
Abraham, NM;Spors, H;Schaefer, AT
通讯作者：
Schaefer, AT
DOI：
10.1073/pnas.88.15.6462
发表时间：
1991-08-01
影响因子：
11.1
作者：
HOPFIELD, JJ
通讯作者：
HOPFIELD, JJ