Active Sampling State Dynamically Enhances Olfactory Bulb Odor Representation.
Active Sampling State Dynamically Enhances Olfactory Bulb Odor Representation.
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DOI：
10.1016/j.neuron.2018.05.016
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发表时间：
2018-06-27
期刊：
影响因子：
16.2
通讯作者：
Schaefer AT
中科院分区：
文献类型：
--
作者：
Jordan R;Fukunaga I;Kollo M;Schaefer AT
嗅球（OB）是嗅觉信息处理的第一个突触部位，但其活动中包含了丰富的背景信息和习得信息。为了研究上下文调制的机制基础，我们使用全细胞记录来测量识别的二尖瓣/簇状细胞（MTCs）中快速学习事件的气味反应。在这些学习过程中，不同的反应变化已经发生在第一个嗅探周期。有动力的小鼠在学习过程中发展出积极的嗅探策略，这些策略与气味反应的变化强烈对应，从而增强气味的表现。在不同的行为状态下诱发快速嗅探表明，主动采样期间的响应变化超过了仅从前馈输入预测的响应变化。最后，反应的变化是高度相关的簇状细胞，但不是二尖瓣细胞，表明有细胞类型的特定影响，在积极采样的气味代表。总之，我们表明，主动采样与快速时间尺度上的OB响应增强密切相关。在快速嗅觉学习过程中，二尖瓣和簇状细胞的反应明显变化这些变化可靠地跟踪主动嗅探的发展这以细胞类型特异性的方式增强了气味的可检测性和可辨别性主动嗅探通过自下而上和自上而下的机制影响气味反应在一系列行为状态下使用小鼠嗅球中的全细胞记录，Jordan et al.表明气味反应在学习和任务参与过程中动态增强，紧密反映了主动嗅探的变化。
The olfactory bulb (OB) is the first site of synaptic odor information processing, yet a wealth of contextual and learned information has been described in its activity. To investigate the mechanistic basis of contextual modulation, we use whole-cell recordings to measure odor responses across rapid learning episodes in identified mitral/tufted cells (MTCs). Across these learning episodes, diverse response changes occur already during the first sniff cycle. Motivated mice develop active sniffing strategies across learning that robustly correspond to the odor response changes, resulting in enhanced odor representation. Evoking fast sniffing in different behavioral states demonstrates that response changes during active sampling exceed those predicted from feedforward input alone. Finally, response changes are highly correlated in tufted cells, but not mitral cells, indicating there are cell-type-specific effects on odor representation during active sampling. Altogether, we show that active sampling is strongly associated with enhanced OB responsiveness on rapid timescales. During rapid olfactory learning, responses of mitral and tufted cells change overtly These changes reliably track the development of active sniffing This enhances odor detectability and discriminability in a cell-type-specific way Active sniffing impacts odor responses through both bottom-up and top-down mechanisms Using whole-cell recordings in the olfactory bulb of mice across a range of behavioral states, Jordan et al. show that odor responses are dynamically enhanced during learning and task engagement, tightly mirroring alterations in active sniffing.
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DOI：
10.1523/jneurosci.4101-12.2013
发表时间：
2013-01-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cenier T;McGann JP;Tsuno Y;Verhagen JV;Wachowiak M
通讯作者：
Wachowiak M
影响因子：
16.2
作者：
Abraham NM;Egger V;Shimshek DR;Renden R;Fukunaga I;Sprengel R;Seeburg PH;Klugmann M;Margrie TW;Schaefer AT;Kuner T
通讯作者：
Kuner T
影响因子：
16.2
作者：
Fukunaga, Izumi;Berning, Manuel;Schaefer, Andreas T.
通讯作者：
Schaefer, Andreas T.
DOI：
10.1016/0013-4694(50)90075-7
发表时间：
1950-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
ADRIAN, ED
通讯作者：
ADRIAN, ED
影响因子：
16.2
作者：
Abraham, NM;Spors, H;Schaefer, AT
通讯作者：
Schaefer, AT