Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis.
Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis.
复制标题
癌胚抗原升高预示着临床无肌病性皮肌炎的快速进展性间质性肺病。
DOI：
10.1093/rheumatology/keaa819
复制
发表时间：
2021
期刊：
影响因子：
5.5
通讯作者：
H. Fang
中科院分区：
文献类型：
--
作者：
Ding;J. Qiao;Shunli Tang;Yunlei Pan;Sheng Li;Changyi Yang;H. Fang
目标
本研究旨在探讨血清癌胚抗原（CEA）水平与临床无肌病性糖尿病（CADM）患者间质性肺病（ILD）严重程度的相关性。
方法
我们进行了一项回顾性研究，包括41例中国CADM患者无恶性肿瘤。收集血清CEA水平、临床和实验室检查结果。进行CEA水平与疾病活动参数之间的关联检验。
结果
41例患者中，16例（39.0%）发生快速进展（RP）-ILD，其中14例（87.5%）血清CEA水平升高。多因素Logistic回归分析显示，血清CEA水平升高是RP-ILD的独立危险因素。RP ILD组CEA升高的发生率明显高于非RP ILD组（87.5vs16.0%，P < 0.001）。CADM伴RP ILD组CEA水平[26.87（6.71）μg/l]高于无RP ILD组[3.23（0.64）μg/l]（P < 0.001）。CADM患者CEA水平与铁蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶水平及肺部CT评分相关。此外，CEA水平升高与机化性肺炎模式和高分辨率CT下肺区实变有关。CEA> 8.75 μ g/l组的累积生存率明显低于CEA <8.75 μ g/l组（68.4vs31.6%，P < 0.001）。
结论
血清CEA水平升高在CADM患者中很常见，并且血清CEA水平升高是这些患者中RP-ILD和预后不良的有力指标。
OBJECTIVES
The present study aimed to determine the correlation between serum carcinoembryonic antigen (CEA) level and the severity of interstitial lung disease (ILD) in clinically amyopathic DM (CADM) patients.
METHODS
We performed a retrospective study including 41 Chinese CADM patients without malignancy. Serum CEA levels, clinical and laboratory findings were collected. Association tests between CEA levels and disease activity parameters were performed.
RESULTS
Among the 41 patients, 16 (39.0%) developed rapidly progressive (RP)-ILD; of them, 14 (87.5%) had elevated serum CEA levels. Multivariate logistic regression analysis indicated that an elevated serum CEA level was an independent risk factor for RP-ILD. The incidence of elevated CEA level was significantly higher in patients with RP-ILD than in those without RP-ILD (87.5 vs 16.0%, P < 0.001). Furthermore, CEA levels were higher in patients with CADM with RP-ILD [26.87 (6.71) μg/l] than in those without RP-ILD [3.23 (0.64) μg/l] (P < 0.001). CEA levels in CADM patients were associated with the ferritin, alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase levels, and CT scores of the lungs. Also, elevated CEA levels are related to the organizing pneumonia pattern and lower lung zone consolidation in high-resolution CT. Moreover, the cumulative survival rate was significantly lower (68.4 vs 31.6%, P < 0.001) in the group with a CEA level >8.75 μg/l than that in the group with a CEA level <8.75 μg/l.
CONCLUSIONS
An elevated serum CEA level is common in patients with CADM, and a higher serum CEA level is a powerful indicator of RP-ILD and poor prognosis in those patients.
影响因子：
6.5
作者：
EUWER, RL;SONTHEIMER, RD
通讯作者：
SONTHEIMER, RD
影响因子：
--
作者：
Bendewald, Margo J.;Wetter, David A.;Li, Xujian;Davis, Mark D. P.
通讯作者：
Davis, Mark D. P.