Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad.
Checks and balances: The glucocorticoid receptor and NFĸB in good times and bad.
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DOI：
10.1016/j.yfrne.2017.05.001
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发表时间：
2017-07
影响因子：
7.4
通讯作者：
Neigh GN
中科院分区：
文献类型：
--
作者：
Bekhbat M;Rowson SA;Neigh GN
内分泌系统和免疫系统之间的相互调节和平衡促进生物体的应激反应，并且在慢性应激或长期免疫激活后受损。应激生理学和免疫力的同时改变越来越被认为是几种与应激相关的神经精神障碍的促成因素，包括抑郁症、焦虑症和创伤后应激障碍。越来越多的证据表明，糖皮质激素受体（GR）和活化B细胞（NFκB）的核因子κ轻链增强子（分别是内分泌和免疫轴的效应子）之间的平衡受损和相互作用可能在介导慢性应激对情绪和行为的有害影响中发挥关键作用。在这里，我们首先回顾了GR和NFκB相互作用的分子机制在健康，然后描述潜在的变化，在慢性应激条件下的脑回路相关的神经精神疾病的背景下，GR-NF κB动力学。此外，我们讨论了这两个转录因子的调节的发展影响和性别差异。
Mutual regulation and balance between the endocrine and immune systems facilitate an organism’s stress response, and are impaired following chronic stress or prolonged immune activation. Concurrent alterations in stress physiology and immunity are increasingly recognized as contributing factors to several stress-linked neuropsychiatric disorders including depression, anxiety, and post-traumatic stress disorder. Accumulating evidence suggests that impaired balance and crosstalk between the glucocorticoid receptor (GR) and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) – effectors of the endocrine and immune axes, respectively – may play a key role in mediating the harmful effects of chronic stress on mood and behavior. Here, we first review the molecular mechanisms of GR and NFκB interactions in health, then describe potential shifts in the GR-NFκB dynamics in chronic stress conditions within the context of brain circuitry relevant to neuropsychiatric diseases. Furthermore, we discuss developmental influences and sex differences in the regulation of these two transcription factors.
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影响因子：
10.6
作者：
Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
3.7
作者：
Binder, E. B.;Kuenzel, H. E.;Holsboer, F.
通讯作者：
Holsboer, F.
影响因子：
30.8
作者：
Binder, EB;Salyakina, D;Muller-Myhsok, B
通讯作者：
Muller-Myhsok, B
DOI：
10.1523/jneurosci.2456-10.2011
发表时间：
2011-04-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Boersma MC;Dresselhaus EC;De Biase LM;Mihalas AB;Bergles DE;Meffert MK
通讯作者：
Meffert MK
影响因子：
3.5
作者：
Bourke, Chase H.;Neigh, Gretchen N.
通讯作者：
Neigh, Gretchen N.