Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic.
Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic.
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DOI：
10.1016/j.yhbeh.2011.03.011
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发表时间：
2011-06
影响因子：
3.5
通讯作者：
Neigh, Gretchen N.
中科院分区：
文献类型：
--
作者：
Bourke, Chase H.;Neigh, Gretchen N.
有证据表明，女性比男性更容易患上与压力相关的疾病。动物研究表明，女性对压力的敏感性类似，并已被用于研究压力对性别的特定影响的潜在神经生物学。尽管近年来我们对青春期慢性应激的性别特异性影响的了解有所增加，但很少有研究报道青春期应激对抑郁样行为的影响。这项研究的目的是确定青春期的慢性混合通道应激源(包括隔离、约束和社交失败)是否导致雄性和雌性Wistar大鼠抑郁样行为的差异和持续性变化。暴露于慢性青春期应激的雌性大鼠在青春期(PND48-57)和成年期(PND96-104)与对照组相比，蔗糖消耗量减少，在高架迷宫中多动，在强迫游泳测试中活动减少，皮质酮对急性强迫游泳应激的反应迟钝(PND48-57)。暴露于青春期慢性应激的雄性大鼠在青春期结束或成年时都没有表现出明显的行为变化。这些数据支持这一命题，即青春期可能是女性的压力敏感期，青春期暴露在压力下会导致在女性身上持续存在的行为影响。研究慢性青春期压力对性别的影响可能有助于更好地了解人类抑郁症和焦虑性障碍的性二相性发病率，并最终改进预防和治疗策略。
Evidence suggests that women are more susceptible to stress-related disorders than men. Animal studies demonstrate a similar female sensitivity to stress and have been used to examine the underlying neurobiology of sex-specific effects of stress. Although our understanding of the sex-specific effects of chronic adolescent stress has grown in recent years, few studies have reported the effects of adolescent stress on depressive-like behavior. The purpose of this study was to determine if a chronic mixed modality stressor (consisting of isolation, restraint, and social defeat) during adolescence (PND37-49) resulted in differential and sustained changes in depressive-like behavior in male and female Wistar rats. Female rats exposed to chronic adolescent stress displayed decreased sucrose consumption, hyperactivity in the elevated plus maze, decreased activity in the forced swim test, and a blunted corticosterone response to an acute forced swim stress compared to controls during both adolescence (PND48-57) and adulthood (PND96-104). Male rats exposed to chronic adolescent stress did not manifest significant behavioral changes at either the end of adolescence or in adulthood. These data support the proposition that adolescence may be a stress sensitive period for females and exposure to stress during adolescence results in behavioral effects that persist in females. Studies investigating the sex-specific effects of chronic adolescent stress may lead to a better understanding of the sexually dimorphic incidence of depressive and anxiety disorders in humans and ultimately improve prevention and treatment strategies.
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