Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers.
Immune phenotype is differentially affected by changing the type of bovine respiratory disease vaccine administered at revaccination in beef heifers.
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DOI：
10.3389/fvets.2023.1161902
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发表时间：
2023
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
在预处理期间，经常在断奶前对肉牛接种改良活疫苗。在本研究中，我们开始表征小牛的免疫表型，这些小牛在3-4月龄时接受改良活疫苗接种，然后在到达饲养场（断奶）和到达后28天（加强）时接受相同的改良活疫苗或灭活疫苗。在再接种前和再接种后14天和28天评估先天性和适应性免疫措施。根据平均细胞因子浓度（IL-17、IL-21）和总免疫球蛋白-G（IgG）以及亚群IgG 1和IgG 2（与适应性免疫系统的两个分支相关）的增加，接受三剂改良活疫苗的小母牛表现出相对平衡的免疫应答。相反，接受一剂改良活疫苗和两剂灭活疫苗的小母牛具有更强的中性粒细胞趋化反应和更高的血清中和抗体滴度，导致先天免疫增强和倾斜的促炎反应。这些结果表明，在初次接种改良活疫苗后使用的再接种方案对肉牛的免疫表型有不同的影响，三种剂量的改良活疫苗诱导潜在的免疫稳态，而改良活疫苗和灭活疫苗的组合诱导偏斜的免疫表型。然而，需要更多的研究来确定这些疫苗接种方案对疾病的保护效力。
During preconditioning, modified-live vaccines are frequently administered to beef calves before weaning. In this study, we began to characterize the immune phenotype of calves that received a modified-live vaccination at 3–4 months of age and then either received the same modified-live or an inactivated vaccine upon arrival at the feedlot (weaning) and 28 days post-arrival (booster). Innate and adaptive immune measures were assessed before revaccination and 14 and 28 days post. Heifers that received three doses of the modified-live vaccine exhibited a relatively balanced immune response based on increases in mean cytokine concentrations (IL-17, IL-21) and total immunoglobulin-G (IgG) and subsets IgG1 and IgG2, which are related to both arms of the adaptive immune system. Conversely, heifers that received one dose of modified live and two doses of the inactivated vaccine had a more robust neutrophil chemotactic response and greater serum-neutralizing antibody titers, resulting in an enhanced innate immune and a skewed proinflammatory response. These results indicate that the revaccination protocol used after initial vaccination with a modified-live vaccine differentially influences the immune phenotype of beef calves, with three doses of modified live inducing potentially immune homeostasis and a combination of modified live and inactivated vaccines inducing a skewed immune phenotype. However, more research is needed to determine the protective efficacy of these vaccination protocols against disease.
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影响因子：
3.5
作者：
Auchtung, TL;Salak-Johnson, JL;Dahl, GE
通讯作者：
Dahl, GE
影响因子：
1.8
作者：
SALAK, JL;MCGLONE, JJ;LYTE, M
通讯作者：
LYTE, M
影响因子：
4.4
作者：
Bálint, A;Baule, C;Belák, S
通讯作者：
Belák, S
影响因子：
3
作者：
Hudson, Rachel E.;Tomczak, Dexter J.;Richeson, John T.
通讯作者：
Richeson, John T.
影响因子：
5.5
作者：
Kalina, WV;Woolums, AR;Gershwin, LJ
通讯作者：
Gershwin, LJ