"ET Plus": Instability of the Diagnosis During Prospective Longitudinal Follow-up of Essential Tremor Cases.
"ET Plus": Instability of the Diagnosis During Prospective Longitudinal Follow-up of Essential Tremor Cases.
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DOI：
10.3389/fneur.2021.782694
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发表时间：
2021
影响因子：
3.4
通讯作者：
Louis ED
中科院分区：
文献类型：
--
作者：
Iglesias-Hernandez D;Delgado N;McGurn M;Huey ED;Cosentino S;Louis ED
背景：最近的一项共识声明提出了“ET+”一词。虽然研究者已经在横断面研究中量化了ET+的患病率，但尚未对ET+患者进行纵向跟踪;因此，尚不了解其随时间的稳定性。研究方法：我们提供了一个ET队列的前瞻性纵向表型数据，该队列以18个月的间隔（T1，T2，T3，T4）定期随访长达64个月。我们在每个时间间隔为每个病例分配了ET或ET+诊断。结果：基线时有201名参与者。ET+的比例从基线时的58.7%增加至T4时的72.1%（p = 0.046）。在172名（85.6%）在一个或多个时间间隔接受ET+诊断的患者中，诊断不稳定（例如，有返原者62例（36.0%）。我们还评估了ET plus临床特征的稳定性。静息震颤是ET+最不稳定的临床特征; 59例参与者中存在，其中23例（39.0%）从存在恢复为不存在。相比之下，对于“记忆障碍”（即，轻度认知功能障碍或痴呆），从在场恢复到缺席的比例仅为21.3%。结论：这些数据支持我们的两个先验假设：（1）ET+的患病率将逐渐增加，因为它可能代表ET的更晚期阶段，（2）ET+诊断不会随着时间的推移而稳定，因为病例会在其表型特征和指定诊断方面波动。
Background: A recent consensus statement introduced the term “ET plus”. Although investigators have quantified the prevalence of ET plus in cross-sectional studies, patients with ET plus have not been tracked longitudinally; hence, there is no understanding of its stability over time. Methods: We present prospective, longitudinal phenotypic data on an ET cohort that was followed regularly at 18-month intervals (T1, T2, T3, T4) for up to 64 months. We assigned an ET or ET plus diagnosis to each case at each time interval. Results: There were 201 participants at baseline. The proportion with ET plus increased from 58.7% at baseline to 72.1% at T4 (p = 0.046). Of 172 (85.6%) who received a diagnosis of ET plus at one or more time intervals, the diagnosis was unstable (e.g., with reversion) in 62 (36.0%). We also assessed the stability of the clinical features of ET plus. Rest tremor was the most unstable clinical feature of ET plus; it was present in 59 participants, among whom it reverted from present to absent in 23 (39.0%). By contrast, for “memory impairment” (i.e., either mild cognitive impairment or dementia), the proportion who reverted from present to absent was only 21.3%. Conclusion: These data support our two a priori hypotheses: (1) the prevalence of ET plus would increase progressively, as it likely represents a more advanced stage of ET, and (2) the ET plus diagnosis would not be stable over time, as cases would fluctuate with respect to their phenotypic features and their assigned diagnoses.
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基本震颤与“ ET-Plus”：小脑病理的详细死后研究。
DOI：
10.1007/s12311-021-01263-6
发表时间：
2021-12
期刊：
Cerebellum (London, England)
影响因子：
--
作者：
Gionco JT;Hartstone WG;Martuscello RT;Kuo SH;Faust PL;Louis ED
通讯作者：
Louis ED
影响因子：
4.1
作者：
Louis ED
通讯作者：
Louis ED
DOI：
10.7916/d8b00nrv
发表时间：
2018-01-01
期刊：
Tremor and other hyperkinetic movements (New York, N.Y.)
影响因子：
--
作者：
Kim, Christine Y;Louis, Elan D
通讯作者：
Louis, Elan D
影响因子：
2.2
作者：
Kim, Christine Y.;Petersen, Maria Skaalum;Louis, Elan D.
通讯作者：
Louis, Elan D.
影响因子：
48
作者：
Louis, Elan D.;Bares, Martin;Benito-Leon, Julian;Fahn, Stanley;Frucht, Steven J.;Jankovic, Joseph;Ondo, William G.;Pal, Pramod K.;Tan, Eng-King
通讯作者：
Tan, Eng-King