Mitochondrial Dysfunction Contributes to Aging-Related Atrial Fibrillation.
Mitochondrial Dysfunction Contributes to Aging-Related Atrial Fibrillation.
复制标题
线粒体功能障碍导致与衰老相关的心房颤动
DOI：
10.1155/2021/5530293
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发表时间：
2021
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Liu C;Bai J;Dan Q;Yang X;Lin K;Fu Z;Lu X;Xie X;Liu J;Fan L;Li Y
心房颤动（AF）的发病率随着年龄的增长而增加，端粒长度随着年龄的增长而逐渐缩短。然而，端粒长度是否与房颤有关尚不明确，衰老导致房颤发病率增加的确切机制也尚不清楚。我们假设端粒长度与衰老相关的房颤有关，线粒体功能障碍在其中起作用。本研究招募2018年4月至10月在中国人民解放军总医院第二医疗中心住院的老年男性房颤患者96例。经年龄、性别匹配后，选取同期入院体检的96例非房颤老年男性患者作为对照。对所有受试者进行人体测量学、临床和实验室分析。检测外周血白细胞线粒体膜电位（MMP）作为线粒体功能的指标。与对照组相比，AF患者白细胞端粒长度（LTL）显著缩短（P < 0.001），血清PGC-1α水平显著降低。此外，在没有任何其他疾病的受试者中，AF患者的MMP比对照组低。多因素logistic回归证实，LTL （OR 0.365, 95% CI 0.235 ~ 0.568, P < 0.001）和血清PGC-1α (OR 0.993, 95% CI 0.988 ~ 0.997, P = 0.002)与AF的存在呈负相关，ROC分析显示LTL和血清PGC-1α的AUC值分别为0.734和0.633，具有潜在的诊断价值。本研究认为，LTL和血清PGC-1α与衰老相关性房颤的发生呈负相关，线粒体功能障碍在其中起作用。
The incidence of atrial fibrillation (AF) increases with age, and telomere length gradually shortens with age. However, whether telomere length is related to AF is still inconclusive, and the exact mechanism by which aging causes the increased incidence of AF is still unclear. We hypothesize that telomere length is correlated with aging-related AF and that mitochondrial dysfunction plays a role in this. This research recruited 96 elderly male patients with AF who were admitted to the Second Medical Center of Chinese PLA General Hospital from April to October 2018. After matching by age and gender, 96 non-AF elderly male patients who were admitted to the hospital for physical examination during the same period were selected as controls. Anthropometric, clinical, and laboratory analyses were performed on all subjects. The mitochondrial membrane potential (MMP) of peripheral blood leukocytes was detected as the indicator of mitochondrial function. Compared with the control group, the leukocyte telomere length (LTL) was significantly shorter (P < 0.001), and the level of PGC-1α in serum was significantly lower in AF patients. Additionally, in subjects without any other diseases, the AF patients had lower MMP when compared with the control. Multivariate logistic regression confirmed that LTL (OR 0.365; 95% CI 0.235-0.568; P < 0.001) and serum PGC-1α (OR 0.993; 95% CI 0.988-0.997; P = 0.002) were inversely associated with the presence of AF. In addition, ROC analysis indicated the potential diagnostic value of LTL and serum PGC-1α with AUC values of 0.734 and 0.633, respectively. This research concludes that LTL and serum PGC-1α are inversely correlated with the occurrence of aging-related AF and that mitochondrial dysfunction plays a role in this.
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影响因子：
4
作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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