Rpl30 and Hmgb1 are required for neurulation in golden hamster.

Rpl30 and Hmgb1 are required for neurulation in golden hamster.
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在金仓鼠中,RPL30和HMGB1是必需的。

DOI:
10.1080/00207450802330504
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发表时间:
2009
期刊:
The International journal of neuroscience
影响因子:
--
通讯作者:
Wang X
Wang X
中科院分区:
其他
文献类型:
--
作者:
Yu L;Guan YJ;Gao Y;Wang X

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Neural tube defects (NTDs) are a group of severe congenital malformations resulting from the failure of neurulation. Genes influencing neurulation have been investigated for their contribution to neural tube defects. Ribosomal protein (Rp) is an abundant and high conservative gene family, which has the complex task of coordinating protein biosynthesis to maintain cell homeostasis and survival. However, the mechanisms of ribosomal protein in the neural tube defects are unknown. Understanding the mechanisms will lead to new insights into neural tube defects. In this report, we constructed a cDNA library from neural tube of golden hamster and screened the cDNA library by a subsection screening method (SSS). Our results demonstrate a possible essential role of the RPL30 cDNA gene during neurulation and in the risk of NTDs. Our study also suggests that another gene, HMGB1, may be significantly associated with neurulation and the risk of NTDs.
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