Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndrome.
Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndrome.
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DOI：
10.1371/journal.pone.0200068
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Newton JL
中科院分区：
文献类型：
--
作者：
Finkelmeyer A;He J;Maclachlan L;Blamire AM;Newton JL
直立不耐受（OI）的症状在慢性疲劳综合征（CFS）和类似疾病中很常见。这些症状可能与颅内顺应性和脑血流灌注的个体差异有关。本研究使用相位对比、定量流动磁共振成像（MRI），根据动脉流入、静脉流出和脑脊液沿着椎管流入和流出颅腔来确定颅内顺应性。使用流量敏感交替反转恢复（FAIR）动脉自旋标记来测量静息时的脑血流灌注。40例CFS患者和10名年龄和性别匹配的对照进行了扫描。OI症状的严重程度通过使用自主神经症状特征的自我报告来确定。CFS患者报告的OI水平显著较高（p <0.001）。在患者组中，OI症状的严重程度越高，颅内顺应性越低（r =-0.346，p = 0.033），静息灌注越高（r = 0.337，p = 0.038）。两组颅内顺应性均与脑灌注呈负相关。两组之间在颅内顺应性或灌注方面无显著差异。在CFS患者中，低颅内顺应性和高静息脑灌注似乎与OI症状的严重程度增加相关。这可能意味着脑血管系统的能力改变，以科普由于立位应激引起的全身血压变化，但这可能不是CFS所特有的。
Symptoms of orthostatic intolerance (OI) are common in Chronic Fatigue Syndrome (CFS) and similar disorders. These symptoms may relate to individual differences in intracranial compliance and cerebral blood perfusion. The present study used phase-contrast, quantitative flow magnetic resonance imaging (MRI) to determine intracranial compliance based on arterial inflow, venous outflow and cerebrospinal fluid flow along the spinal canal into and out of the cranial cavity. Flow-sensitive Alternating Inversion Recovery (FAIR) Arterial Spin Labelling was used to measure cerebral blood perfusion at rest. Forty patients with CFS and 10 age and gender matched controls were scanned. Severity of symptoms of OI was determined from self-report using the Autonomic Symptom Profile. CFS patients reported significantly higher levels of OI (p < .001). Within the patient group, higher severity of OI symptoms were associated with lower intracranial compliance (r = -.346, p = .033) and higher resting perfusion (r = .337, p = .038). In both groups intracranial compliance was negatively correlated with cerebral perfusion. There were no significant differences between the groups in intracranial compliance or perfusion. In patients with CFS, low intracranial compliance and high resting cerebral perfusion appear to be associated with an increased severity of symptoms of OI. This may signify alterations in the ability of the cerebral vasculature to cope with changes to systemic blood pressure due to orthostatic stress, but this may not be specific to CFS.
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