Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system.
Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system.
复制标题
DOI：
10.1093/infdis/jir845
复制
发表时间：
2012-03-01
期刊：
影响因子：
--
通讯作者：
Massey RC
中科院分区：
文献类型：
--
作者：
Rudkin JK;Edwards AM;Bowden MG;Brown EL;Pozzi C;Waters EM;Chan WC;Williams P;O'Gara JP;Massey RC
成功治疗由耐甲氧西林金黄色葡萄球菌（MRSA）引起的感染的困难导致它们被称为高毒性或致病性。在我们对一种主要的医疗保健相关MRSA（HA-MRSA）克隆的研究中，我们表明，负责赋予甲氧西林耐药性（mecA）的基因的表达也直接负责降低HA-MRSA分泌溶细胞毒素的能力。我们发现，对甲氧西林的耐药性诱导了细胞壁的变化，从而影响了细菌的agr群体感应系统。这导致减少的毒素表达，并因此在败血症的鼠模型中降低毒力。这种导致感染的能力减弱可能解释了HA-MRSA无法进入社区，并帮助我们了解最近出现的社区相关MRSA（CA-MRSA）。CA-MRSA通常表达较少的青霉素结合蛋白2a（由mecA编码），使它们能够保持完整的毒力并在社区环境中取得成功。
The difficulty in successfully treating infections caused by methicillin-resistant Staphylococcus aureus (MRSA) has led to them being referred to as highly virulent or pathogenic. In our study of one of the major healthcare-associated MRSA (HA-MRSA) clones, we show that expression of the gene responsible for conferring methicillin resistance (mecA) is also directly responsible for reducing the ability of HA-MRSA to secrete cytolytic toxins. We show that resistance to methicillin induces changes in the cell wall, which affects the bacteria's agr quorum sensing system. This leads to reduced toxin expression and, as a consequence, reduced virulence in a murine model of sepsis. This diminished capacity to cause infection may explain the inability of HA-MRSA to move into the community and help us understand the recent emergence of community-associated MRSA (CA-MRSA). CA-MRSA typically express less penicillin-binding protein 2a (encoded by mecA), allowing them to maintain full virulence and succeed in the community environment.
登录
查看更多内容
影响因子：
168.9
作者：
DeLeo, Frank R.;Otto, Michael;Kreiswirth, Barry N.;Chambers, Henry F.
通讯作者：
Chambers, Henry F.
影响因子：
3.7
作者：
NOVICK, R
通讯作者：
NOVICK, R
影响因子：
9.4
作者：
Okuma, K;Iwakawa, K;Hiramatsu, K
通讯作者：
Hiramatsu, K
影响因子：
6.7
作者：
Kaito C;Saito Y;Nagano G;Ikuo M;Omae Y;Hanada Y;Han X;Kuwahara-Arai K;Hishinuma T;Baba T;Ito T;Hiramatsu K;Sekimizu K
通讯作者：
Sekimizu K
影响因子：
2.6
作者：
Corrigan, Rebecca M.;Foster, Timothy J.
通讯作者：
Foster, Timothy J.