Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
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DOI：
10.1038/ncomms1677
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发表时间：
2012-02-14
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞因子激活的中性粒细胞是已知的是必不可少的保护免受A组链球菌感染。然而，在伴有中性粒细胞减少症的严重侵袭性A组链球菌感染期间，尚不清楚哪些因素对此类感染具有保护作用，以及哪些细胞群是它们的来源。在这里，我们发现，感染严重侵袭性A组链球菌分离株的小鼠，而不是非侵袭性A组链球菌分离株，在感染的早期阶段表现出高浓度的血浆干扰素-γ。干扰素-γ是保护小鼠所必需的，由一种新型的具有环形核的粒细胞-巨噬细胞集落刺激因子依赖性未成熟骨髓细胞群产生。这些产生干扰素-γ的未成熟髓样细胞表达单核细胞和粒细胞标志物，并且还产生一氧化氮。过继转移产生干扰素-γ的未成熟髓样细胞可改善野生型和干扰素-γ缺陷小鼠的感染我们的研究结果表明，产生干扰素-γ的未成熟髓样细胞在严重侵袭性A组链球菌感染的早期阶段具有保护作用。髓样细胞在对侵袭性A组链球菌严重感染的反应中是重要的。在这项研究中，具有产生干扰素-γ的环形核的未成熟骨髓细胞的独特群体被证明对于保护小鼠免受早期侵袭性感染是重要的。
Cytokine-activated neutrophils are known to be essential for protection against group A Streptococcus infections. However, during severe invasive group A Streptococcus infections that are accompanied by neutropenia, it remains unclear which factors are protective against such infections, and which cell population is the source of them. Here we show that mice infected with severe invasive group A Streptococcus isolates, but not with non-invasive group A Streptococcus isolates, exhibit high concentrations of plasma interferon-γ during the early stage of infection. Interferon-γ is necessary to protect mice, and is produced by a novel population of granulocyte–macrophage colony-stimulating factor-dependent immature myeloid cells with ring-shaped nuclei. These interferon-γ-producing immature myeloid cells express monocyte and granulocyte markers, and also produce nitric oxide. The adoptive transfer of interferon-γ-producing immature myeloid cells ameliorates infection in wild-type and interferon-γ-deficient mice. Our results indicate that interferon-γ-producing immature myeloid cells have a protective role during the early stage of severe invasive group A Streptococcus infections. Myeloid cells are important in the response to severe infection by invasive Streptococcus Group A. In this study, a distinct population of immature myeloid cells with ring shaped nuclei that produce interferon-γ are shown to be important for protection of mice against the early stages of invasive infection.
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影响因子：
158.5
作者：
Davies, HD;McGeer, A;Naus, M
通讯作者：
Naus, M
影响因子：
6.4
作者：
Goldmann, O;Chhatwal, GS;Medina, E
通讯作者：
Medina, E
影响因子：
4.4
作者：
Liu, F;Whitton, JL
通讯作者：
Whitton, JL
影响因子：
6.4
作者：
Goldmann, O;Chhatwal, GS;Medina, E
通讯作者：
Medina, E
DOI：
10.1001/jama.1993.03500030088038
发表时间：
1993-01-20
影响因子：
120.7
作者：
BREIMAN, RF;DAVIS, JP;TODD, JK
通讯作者：
TODD, JK