Detection of waterborne parasites using field-portable and cost-effective lensfree microscopy.
Detection of waterborne parasites using field-portable and cost-effective lensfree microscopy.
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DOI：
10.1039/c004829a
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发表时间：
2010-09-21
期刊：
影响因子：
6.1
通讯作者：
Ozcan A
中科院分区：
文献类型：
--
作者：
Mudanyali O;Oztoprak C;Tseng D;Erlinger A;Ozcan A
通过水质管理保护人类健康和福祉是世界发达地区和发展中地区的一个重要目标。与此同时，消毒技术的不足仍然无法消除淡水和娱乐水资源中的病原污染物。因此，非常需要对水质进行筛选，以防止水传播疾病的爆发和与水有关的疾病的事件。为此，我们研究了一种低浓度的野外便携式无透镜全息显微镜，用于成像和检测致病性原生动物寄生虫，如贾第鞭毛虫和细小隐孢子虫。这种紧凑的无透镜显微镜（O. Mudanyali et al., Lab Chip, 2010, 10, 1417-1428），重约46克，在成像视场上实现了约0.1-0.2的数值孔径，比典型的10倍物镜大一个数量级以上，因此可以为防治水传播疾病提供重要的高吞吐量分析工具，特别是在资源有限的情况下。
Protection of human health and well-being through water quality management is an important goal for both the developed and the developing parts of the world. In the meantime, insufficient disinfection techniques still fail to eliminate pathogenic contaminants in freshwater as well as recreational water resources. Therefore, there is a significant need for screening of water quality to prevent waterborne outbreaks and incidents of water-related diseases. Toward this end, here we investigate the use of a field-portable and cost-effective lensfree holographic microscope to image and detect pathogenic protozoan parasites such as Giardia Lamblia and Cryptosporidium Parvum at low concentration levels. This compact lensless microscope (O. Mudanyali et al., Lab Chip, 2010, 10, 1417–1428), weighing ~46 grams, achieves a numerical aperture of ~0.1–0.2 over an imaging field of view that is more than an order of magnitude larger than a typical 10X objective lens, and therefore may provide an important high-throughput analysis tool for combating waterborne diseases especially in resource limited settings.
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影响因子：
6.1
作者：
Seo S;Su TW;Tseng DK;Erlinger A;Ozcan A
通讯作者：
Ozcan A
影响因子：
7.4
作者：
Seo, Sungkyu;Isikman, Serhan O.;Sencan, Ikbal;Mudanyali, Onur;Su, Ting-Wei;Bishara, Waheb;Erlinger, Anthony;Ozcan, Aydogan
通讯作者：
Ozcan, Aydogan
影响因子：
7.4
作者：
Maalouf, Rita;Fournier-Wirth, Chantal;Jaffrezic-Renault, Nicole
通讯作者：
Jaffrezic-Renault, Nicole
影响因子：
7.4
作者：
Ahn, S;Walt, DR
通讯作者：
Walt, DR
影响因子：
12.8
作者：
Hammes, Frederik;Berney, Michael;Egli, Thomas
通讯作者：
Egli, Thomas