Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans.
Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans.
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DOI：
10.1007/978-81-322-1777-0_6
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发表时间：
2014
影响因子：
--
通讯作者：
Talbot PJ
中科院分区：
文献类型：
--
作者：
Desforges M;Le Coupanec A;Brison E;Meessen-Pinard M;Talbot PJ
在人类中，呼吸道的病毒感染是世界范围内发病率和死亡率的主要原因。几种公认的呼吸道病毒因子具有神经侵入能力，因为它们可以从呼吸道传播到中枢神经系统（CNS）。一旦感染中枢神经系统细胞（嗜神经性），可能导致人类健康问题，如脑炎和长期神经系统疾病。在各种呼吸道病毒中，冠状病毒是人和动物的重要病原体。人类冠状病毒（HCoV）通常感染上呼吸道，主要与普通感冒有关。然而，在更脆弱的人群中，如新生儿，婴儿，老年人和免疫受损的个体，它们也会影响下呼吸道，导致肺炎，哮喘加重，呼吸窘迫综合征，甚至严重急性呼吸综合征（SARS）。自20世纪60年代以来，HCoV的呼吸系统受累已经明确确立。此外，近三十年来，科学文献也证明HCoV具有神经侵袭性和嗜神经性，并可能诱导免疫系统的过度激活，部分原因是参与激活可能与易感个体自身免疫相关的自身反应性免疫细胞。此外，研究表明，在鼠CNS中，神经元是感染的主要靶标，这导致这些必需细胞经历变性，并最终在病毒感染后通过某种形式的程序性细胞死亡而死亡。此外，病毒表面糖蛋白（S）似乎是神经退行性过程中的一个重要因素。鉴于所有这些特性，已经表明这些公认的人类呼吸道病原体可能与神经系统疾病的触发或恶化有关，而神经系统疾病的病因仍然未知或知之甚少。
In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Several recognized respiratory viral agents have a neuroinvasive capacity since they can spread from the respiratory tract to the central nervous system (CNS). Once there, infection of CNS cells (neurotropism) could lead to human health problems, such as encephalitis and long-term neurological diseases. Among the various respiratory viruses, coronaviruses are important pathogens of humans and animals. Human Coronaviruses (HCoV) usually infect the upper respiratory tract, where they are mainly associated with common colds. However, in more vulnerable populations, such as newborns, infants, the elderly, and immune-compromised individuals, they can also affect the lower respiratory tract, leading to pneumonia, exacerbations of asthma, respiratory distress syndrome, or even severe acute respiratory syndrome (SARS). The respiratory involvement of HCoV has been clearly established since the 1960s. In addition, for almost three decades now, the scientific literature has also demonstrated that HCoV are neuroinvasive and neurotropic and could induce an overactivation of the immune system, in part by participating in the activation of autoreactive immune cells that could be associated with autoimmunity in susceptible individuals. Furthermore, it was shown that in the murine CNS, neurons are the main target of infection, which causes these essential cells to undergo degeneration and eventually die by some form of programmed cell death after virus infection. Moreover, it appears that the viral surface glycoprotein (S) represents an important factor in the neurodegenerative process. Given all these properties, it has been suggested that these recognized human respiratory pathogens could be associated with the triggering or the exacerbation of neurological diseases for which the etiology remains unknown or poorly understood.
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DOI：
10.1016/j.clim.2007.02.002
发表时间：
2007-06
期刊：
Clinical immunology (Orlando, Fla.)
影响因子：
--
作者：
Boucher A;Desforges M;Duquette P;Talbot PJ
通讯作者：
Talbot PJ
影响因子：
2.9
作者：
Carmen J;Rothstein JD;Kerr DA
通讯作者：
Kerr DA
影响因子：
6.4
作者：
Chan, Jasper Fuk-Woo;Chan, Kwok-Hung;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
11.8
作者：
Cesario, Thomas C.
通讯作者：
Cesario, Thomas C.
影响因子：
5.1
作者：
Cusick MF;Libbey JE;Fujinami RS
通讯作者：
Fujinami RS