Iron Promotes Intestinal Development in Neonatal Piglets.
Iron Promotes Intestinal Development in Neonatal Piglets.
复制标题
铁促进新生仔猪肠道发育
作者：
Pu Y;Li S;Xiong H;Zhang X;Wang Y;Du H
早期营养是促进肠道生长和免疫系统教育的关键。虽然缺铁性贫血长期以来被认为是一种严重的铁紊乱，但补铁对肠道发育的影响尚不清楚。因此，本研究以哺乳仔猪为缺铁模型，探讨补铁对仔猪血液学、肠道发育和免疫功能的影响。在仔猪出生后第3天通过肌肉注射给药胃肠外供应右旋糖酐铁（FeDex，60 mg Fe/kg），并在2日龄、5日龄、10日龄和20日龄屠宰。预期FeDex补铁通过调节铁调素和膜铁转运蛋白（FPN）的相互作用改善铁状态，血清铁、铁蛋白、转铁蛋白和肝脏铁负荷水平较高。补充FeDex增加绒毛长度和隐窝深度，减轻十二指肠的病理状态，并有利于肠粘膜。FeDex还通过刺激肠道细胞因子的产生和增强单核细胞的吞噬能力影响肠道免疫发育。总的来说，本研究表明，铁补充剂有助于促进肠道的发育，通过改善其形态，保持其粘膜的完整性和增强免疫相关因子的表达。
Early nutrition is key to promoting gut growth and education of the immune system. Although iron deficiency anemia has long been recognized as a serious iron disorder, the effects of iron supplementation on gut development are less clear. Therefore, using suckling piglets as the model for iron deficiency, we assessed the impacts of iron supplementation on hematological status, gut development, and immunity improvement. Piglets were parenterally supplied with iron dextran (FeDex, 60 mg Fe/kg) by intramuscular administration on the third day after birth and slaughtered at the age of two days, five days, 10 days, and 20 days. It was expected that iron supplementation with FeDex improved the iron status with higher levels of serum iron, ferritin, transferrin, and iron loading in the liver by regulating the interaction of hepcidin and ferroportin (FPN). FeDex supplementation increased villus length and crypt depth, attenuated the pathological status of the duodenum, and was beneficial to intestinal mucosa. FeDex also influenced the intestinal immune development by stimulating the cytokines’ production of the intestine and enhancing the phagocytotic capacity of monocytes. Overall, the present study suggested that iron supplementation helped promote the development of the intestine by improving its morphology, which maintains its mucosal integrity and enhances the expression of immuno-associated factors.
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影响因子：
2.5
作者：
Clark, Susan F.
通讯作者：
Clark, Susan F.
影响因子：
2.4
作者：
Egeli, AK;Framstad, T
通讯作者：
Framstad, T
影响因子：
3
作者：
Rao, Raghavendra;Georgieff, Michael K.
通讯作者：
Georgieff, Michael K.
影响因子：
3.7
作者：
Bonaccorsi-Riani E;Danger R;Lozano JJ;Martinez-Picola M;Kodela E;Mas-Malavila R;Bruguera M;Collins HL;Hider RC;Martinez-Llordella M;Sanchez-Fueyo A
通讯作者：
Sanchez-Fueyo A
影响因子：
4.8
作者：
Watson A;Lipina C;McArdle HJ;Taylor PM;Hundal HS
通讯作者：
Hundal HS