Decreased Connection Between Reward Systems and Paralimbic Cortex in Depressive Patients.
Decreased Connection Between Reward Systems and Paralimbic Cortex in Depressive Patients.
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抑郁症患者的奖励系统和旁边缘皮层之间的联系减少
DOI：
10.3389/fnins.2018.00462
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发表时间：
2018
影响因子：
4.3
通讯作者：
Wang K
中科院分区：
文献类型：
--
作者：
Bai T;Zu M;Chen Y;Xie W;Cai C;Wei Q;Ji GJ;Tian Y;Wang K
尽管对抑郁症进行了数十年的研究，但抑郁症的潜在病理生理学仍不完全清楚。来自任务型研究的新证据表明，与奖赏相关的异常处理有助于抑郁症的发展。抑郁症患者静息状态下奖赏相关回路的功能模式尚不清楚。在本研究中，基于种子的功能连接性被用来评估安静状态下奖赏相关回路的功能模式。选择的种子是奖赏加工的两个关键节点，内侧眶前皮质(MOFC)和伏隔核(NAcc)。本研究包括50名抑郁症患者和57名健康受试者。采用汉密尔顿抑郁量表和汉密尔顿焦虑量表评定受试者的临床严重程度。结果发现，抑郁症患者右侧MOFC与左侧颞叶的连通性降低(TP_L)，右侧脑岛延伸至颞上回的连通性降低(INS_R/STG)，右侧MOFC与左侧楔前叶的连通性增强。同样，抑郁症患者左侧mOFC与TP_L的连通性降低，与楔叶的连通性增加。右侧NAcc与双侧颞极的连接性降低，左侧NAcc与INS_R/STG的连接性降低。此外，右侧伏核与右侧颞极(TP_R)的功能连接与临床严重程度呈负相关。我们的结果强调了奖赏系统和边缘旁皮质之间的通信缺陷在抑郁症的病理生理学中的作用。
Despite decades of research on depression, the underlying pathophysiology of depression remains incompletely understood. Emerging evidence from task-based studies suggests that the abnormal reward-related processing contribute to the development of depression. It is unclear about the function pattern of reward-related circuit during resting state in depressive patients. In present study, seed-based functional connectivity was used to evaluate the functional pattern of reward-related circuit during resting state. Selected seeds were two key nodes in reward processing, medial orbitofrontal cortex (mOFC) and nucleus accumbens (NAcc). Fifty depressive patients and 57 healthy participants were included in present study. Clinical severity of participants was assessed with Hamilton depression scale and Hamilton anxiety scale. We found that compared with healthy participants, depressive patients showed decreased connectivity of right mOFC with left temporal pole (TP_L), right insula extending to superior temporal gyrus (INS_R/STG) and increased connectivity of right mOFC with left precuneus. Similarly, decreased connectivity of left mOFC with TP_L and increased connectivity with cuneus were found in depressive patients. There is also decreased connectivity of right NAcc with bilateral temporal pole, as well as decreased connectivity of left NAcc with INS_R/STG. In addition, the functional connectivity of right nucleus accumbens with right temporal pole (TP_R) was negatively correlated with clinical severity. Our results emphasize the role of communication deficits between reward systems and paralimbic cortex in the pathophysiology of depression.
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影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
抗精神病药 - 不依次的第一集精神分裂症中固有连通性网络的改变。
影响因子：
6.6
作者：
Anhøj S;Ødegaard Nielsen M;Jensen MH;Ford K;Fagerlund B;Williamson P;Glenthøj B;Rostrup E
通讯作者：
Rostrup E
影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
Markou A
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C