Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study.
Disrupted thalamocortical connectivity in PSP: a resting-state fMRI, DTI, and VBM study.
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DOI：
10.1016/j.parkreldis.2011.05.013
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发表时间：
2011-09
影响因子：
4.1
通讯作者：
Josephs KA
中科院分区：
文献类型：
--
作者：
Whitwell JL;Avula R;Master A;Vemuri P;Senjem ML;Jones DT;Jack CR Jr;Josephs KA
进行性核上性麻痹(PSP)与齿状核丘脑束和运动前皮质的病理改变有关。我们的目的是评估PSP中功能神经连接是否沿着这一途径被破坏，并确定功能变化如何与结构和扩散的变化相关。18名可能的PSP患者和18名对照组进行了静息状态(无任务)功能磁共振成像、扩散张量成像和结构磁共振成像。丘脑和大脑的其他部分以及基底节、突起和默认模式网络(DMN)之间的功能连接被评估。使用基于体素的形态计量学来评估萎缩的模式，并且使用基于束的空间统计学来评估白质束退化的模式。PSP患者丘脑与运动前皮质包括补充运动区(SMA)、纹状体、丘脑和小脑之间的同相功能连接减弱。运动前皮质、纹状体和丘脑在基底节网络和DMN的连接性降低，皮质下突起网络减少。小脑与丘脑及上纵束间束变性，额叶、运动前皮质、SMA和尾状核灰质丢失。SMA功能连通性与SMA体积以及认知和运动功能障碍的测量相关，而丘脑连通性与小脑上脚退行性变相关。因此，PSP与丘脑皮质连接受损有关，而丘脑齿状核束的退化和皮质萎缩的存在与此相关。
Progressive supranuclear palsy (PSP) is associated with pathological changes along the dentatorubrothalamic tract and in premotor cortex. We aimed to assess whether functional neural connectivity is disrupted along this pathway in PSP, and to determine how functional changes relate to changes in structure and diffusion. Eighteen probable PSP subjects and 18 controls had resting-state (task-free) fMRI, diffusion tensor imaging and structural MRI. Functional connectivity was assessed between thalamus and the rest of the brain, and within the basal ganglia, salience and default mode networks (DMN). Patterns of atrophy were assessed using voxel-based morphometry, and patterns of white matter tract degeneration were assessed using tract-based spatial statistics. Reduced in-phase functional connectivity was observed between the thalamus and premotor cortex including supplemental motor area (SMA), striatum, thalamus and cerebellum in PSP. Reduced connectivity in premotor cortex, striatum and thalamus were observed in the basal ganglia network and DMN, with subcortical salience network reductions. Tract degeneration was observed between cerebellum and thalamus and in superior longitudinal fasciculus, with grey matter loss in frontal lobe, premotor cortex, SMA and caudate. SMA functional connectivity correlated with SMA volume and measures of cognitive and motor dysfunction, while thalamic connectivity correlated with degeneration of superior cerebellar peduncles. PSP is therefore associated with disrupted thalamocortical connectivity that is associated with degeneration of the dentatorubrothalamic tract and the presence of cortical atrophy.
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影响因子：
11
作者：
Padovani, A;Borroni, B;Perani, D
通讯作者：
Perani, D
影响因子：
--
作者：
Whitwell, Jennifer L.;Master, Ankit V.;Josephs, Keith A.
通讯作者：
Josephs, Keith A.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
14.5
作者：
Revesz, T;Sangha, H;Daniel, SE
通讯作者：
Daniel, SE