Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation.
Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation.
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在 3D 绘制的羟基磷灰石支架上构建 Sr2 取代的表面羟基磷灰石六角形微阵列以调节成骨分化
DOI：
10.3390/nano10091672
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发表时间：
2020-08-26
期刊：
影响因子：
--
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Wei Y;Gao H;Hao L;Shi X;Wang Y
表面形貌和化学特性可以调节干细胞的增殖和分化，缩短骨愈合时间。然而，表面结构和化学线索在骨再生修复中的协同作用却很少被研究。在此，锶离子（Sr 2+）取代的表面羟基磷灰石（HA）六边形样的阵列被成功地构建在三维绘制的HA多孔支架通过水热反应，以产生形貌和化学双线索。Sr 2+取代的表面微阵列的晶相为HA，而Sr 2+取代的微阵列的晶格常数随着Sr 2+取代量的增加而增加。Sr 2+替代微阵列可实现Sr 2+的持续释放，即使在无成骨诱导培养基的情况下，也能有效促进人脂肪干细胞（ADSCs）向成骨细胞分化。成骨特性最佳增强使用较高的Sr 2+取代的表面微阵列（8 Sr-HA）。支架表面Sr 2+取代的微阵列有望提高HA多孔支架的成骨性能。这些结果表明，Sr 2+取代的HA表面六边形阵列的3D绘制的HA支架具有良好的生物学性能的骨再生修复支架。
Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was rarely studied. Herein, a strontium ion (Sr2+)-substituted surface hydroxyapatite (HA) hexagon-like microarray was successfully constructed on 3D-plotted HA porous scaffold through hydrothermal reaction to generate topography and chemical dual cues. The crystal phase of the Sr2+-substituted surface microarray was HA, while the lattice constant of the Sr2+-substituted microarray increased with increasing Sr2+-substituted amount. Sr2+-substituted microarray could achieve the sustainable release of Sr2+, which could effectively promote osteogenic differentiation of human adipose-derived stem cells (ADSCs) even without osteogenic-induced media. Osteogenic characteristics were optimally enhanced using the higher Sr2+-substituted surface microarray (8Sr-HA). Sr2+-substituted microarray on the scaffold surface could future improve the osteogenic performance of HA porous scaffold. These results indicated that the Sr2+-substituted HA surface hexagon-like microarray on 3D-plotted HA scaffolds had promising biological performance for bone-regeneration repair scaffold.
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