Circadian rhythms in cardiac metabolic flexibility.

Circadian rhythms in cardiac metabolic flexibility.
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DOI:
10.1080/07420528.2021.1939366
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发表时间:
2023-01
影响因子:
2.8
通讯作者:
Latimer MN
Latimer MN
中科院分区:
医学4区
文献类型:
--
作者:
Young ME;Latimer MN

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心血管生理学的许多方面(例如,心率,血压)和病理学(例如,心肌梗塞和心脏性猝死)表现出时间依赖性。与能量需求和底物可用性的昼夜差异相关联,健康的心脏通过对常见底物(葡萄糖、脂质、氨基酸)的代谢命运进行时间划分而显示出显著的代谢灵活性。本综述的目的是强调生物钟对心脏代谢24小时波动的贡献,并讨论通过调整营养摄入时间来减弱和/或增强这些代谢节律是否会影响心血管疾病的发展。
Numerous aspects of cardiovascular physiology (e.g., heart rate, blood pressure) and pathology (e.g., myocardial infarction and sudden cardiac death) exhibit time-of-day-dependency. In association with day-night differences in energetic demand and substrate availability, the healthy heart displays remarkable metabolic flexibility, through temporal partitioning the metabolic fate of common substrates (glucose, lipid, amino acids). The purpose of this review is to highlight the contribution that circadian clocks provide towards 24-hr fluctuations in cardiac metabolism, and to discuss whether attenuation and/or augmentation of these metabolic rhythms through adjustment of nutrient intake timing impacts cardiovascular disease development.
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