Circadian rhythms in cardiac metabolic flexibility.
Circadian rhythms in cardiac metabolic flexibility.
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DOI:
10.1080/07420528.2021.1939366
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发表时间:
2023-01
影响因子:
2.8
通讯作者:
Latimer MN
中科院分区:
文献类型:
--
作者:
Young ME;Latimer MN
Numerous aspects of cardiovascular physiology (e.g., heart rate, blood pressure) and pathology (e.g., myocardial infarction and sudden cardiac death) exhibit time-of-day-dependency. In association with day-night differences in energetic demand and substrate availability, the healthy heart displays remarkable metabolic flexibility, through temporal partitioning the metabolic fate of common substrates (glucose, lipid, amino acids). The purpose of this review is to highlight the contribution that circadian clocks provide towards 24-hr fluctuations in cardiac metabolism, and to discuss whether attenuation and/or augmentation of these metabolic rhythms through adjustment of nutrient intake timing impacts cardiovascular disease development.
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