Theta-coupled periodic replay in working memory.
Theta-coupled periodic replay in working memory.
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DOI：
10.1016/j.cub.2010.01.057
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发表时间：
2010-04-13
期刊：
影响因子：
--
通讯作者：
Düzel E
中科院分区：
文献类型：
--
作者：
Fuentemilla L;Penny WD;Cashdollar N;Bunzeck N;Düzel E
工作记忆允许短暂事件的信息以活跃的神经表征形式持续存在，可以用于目标导向的行为，如决策和学习。基于动物神经元放电模式的计算模型表明，工作记忆的一种假定机制是由θ（4-8赫兹）和γ（30-80赫兹）频率的神经振荡协调的已保存信息的周期性再激活（以下称为“重放”）。为了研究这种可能性，我们训练了多变量模式分类器解码算法，对描绘自然场景的图像的振荡大脑反应进行了训练，这些图像是通过脑磁图以高时间分辨率记录的。这些分类器被应用于在随后的五秒钟的场景维护中记录的大脑活动。这个解码揭示了在整个维护间隔期间的重播。回放是特定于室内还是室外场景的维护，以及维护是集中于场景元素的结构关联还是仅仅是单个场景元素。回放由θ波相位协调，θ波协调量与工作记忆表现相关。通过证实一个机制模型的预测，并将其与人类的行为表现联系起来，这些发现确定了theta耦合重放是工作记忆维持的一种机制。
Working memory allows information from transient events to persist as active neural representations that can be used for goal-directed behaviors such as decision making and learning. Computational modeling based on neuronal firing patterns in animals suggests that one putative mechanism enabling working memory is periodic reactivation (henceforth termed “replay”) of the maintained information coordinated by neural oscillations at theta (4–8 Hz) and gamma (30–80 Hz) frequency. To investigate this possibility, we trained multivariate pattern classifier decoding algorithms on oscillatory brain responses to images depicting natural scenes, recorded with high temporal resolution via magnetoencephalography. These classifiers were applied to brain activity recorded during the subsequent five second maintenance of the scenes. This decoding revealed replay during the entire maintenance interval. Replay was specific to whether an indoor or an outdoor scene was maintained and whether maintenance centered on configural associations of scene elements or just single scene elements. Replay was coordinated by the phase of theta and the amount of theta coordination was correlated with working memory performance. By confirming the predictions of a mechanistic model and linking these to behavioral performance in humans, these findings identify theta-coupled replay as a mechanism of working memory maintenance.
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