Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm.
Entrainment of neocortical neurons and gamma oscillations by the hippocampal theta rhythm.
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DOI：
10.1016/j.neuron.2008.09.014
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发表时间：
2008-11-26
期刊：
影响因子：
16.2
通讯作者：
Buzsáki G
中科院分区：
文献类型：
--
作者：
Sirota A;Montgomery S;Fujisawa S;Isomura Y;Zugaro M;Buzsáki G
虽然人们默认海马体对新皮质网络施加影响，但这一过程的机制尚未得到很好的理解。我们通过记录包括体感区和前额叶皮质在内的多个皮层区域的单细胞群和瞬态伽马振荡，研究了海马θ波振荡是否以及如何影响新皮层的组装模式。对新皮层伽马暴的层流分析揭示了多个频率和位置不同的伽马振荡，它们是空间上受限和同步的局部神经元群。相当一部分假定的锥体细胞和中间神经元以及所有记录的新皮质区域的局部伽马振荡都受到海马θ节律的相位偏偏。我们假设，新皮层伽马振荡与海马theta的时间协调是一种机制，通过这种机制，包含在空间广泛的新皮层集合中的信息可以同步转移到海马体的联合网络。
Although it has been tacitly assumed that the hippocampus exerts an influence on neocortical networks, the mechanisms of this process are not well understood. We examined whether and how hippocampal theta oscillations affect neocortical assembly patterns by recording populations of single cells and transient gamma oscillations in multiple cortical regions, including the somatosensory area and prefrontal cortex in behaving rats and mice. Laminar analysis of neocortical gamma bursts revealed multiple gamma oscillators of varying frequency and location, which were spatially confined and synchronized local groups of neurons. A significant fraction of putative pyramidal cells and interneurons as well as localized gamma oscillations in all recorded neocortical areas were phase-biased by the hippocampal theta rhythm. We hypothesize that temporal coordination of neocortical gamma oscillators by hippocampal theta is a mechanism by which information contained in spatially widespread neocortical assemblies can be synchronously transferred to the associative networks of the hippocampus.
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