Membrane budding.

Membrane budding.
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DOI:
10.1016/j.cell.2010.11.030
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发表时间:
2010-12-10
期刊:
影响因子:
64.5
通讯作者:
Różycki B
Różycki B
中科院分区:
生物学1区
文献类型:
--
作者:
Hurley JH;Boura E;Carlson LA;Różycki B

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膜出芽是囊泡运输、多泡体和外泌体生物合成以及包膜病毒释放的关键步骤。包被囊泡的形成,这通常涉及到向胞质溶胶出芽,代表了一种蛋白质驱动的膜出芽途径,适合于其在细胞内蛋白质分选中的功能。病毒和毒素进入细胞的某些情况,以及动物细胞中的微区依赖性多泡体生物发生,是主要脂质驱动范例的例子。小窝生物发生,HIV-1出芽,也许ESCRT催化的多泡体生物发生涉及蛋白质支架和膜微区范例的方面。后者的一些事件涉及出芽远离胞质溶胶,这种不寻常的拓扑结构涉及新的机制。这些不同的范例的结构和能量基础的进展将被讨论。
Membrane budding is a key step in vesicular transport, multivesicular body and exosome biogenesis, and enveloped virus release. Coated vesicle formation, which is usually involved in budding towards cytosol, represents a protein-driven pathway of membrane budding suited to its function in intracellular protein sorting. Certain instances of cell entry by viruses and toxins, and microdomain-dependent multivesicular body biogenesis in animal cells, are examples of a mainly lipid-driven paradigm. Caveolae biogenesis, HIV-1 budding, and perhaps ESCRT-catalyzed multivesicular body biogenesis involve aspects of both the protein scaffold and membrane microdomain paradigms. Some of these latter events involve budding away from cytosol, and this unusual topology involves novel mechanisms. Progress in the structural and energetic bases of these different paradigms will be discussed.
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