Axial compartmentation of descending and ascending thin limbs of Henle's loops.
Axial compartmentation of descending and ascending thin limbs of Henle's loops.
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亨利袢的下降和上升细肢的轴向分隔。
DOI：
10.1152/ajprenal.00547.2012
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Pannabecker,ThomasL
中科院分区：
文献类型：
--
作者：
Westrick,KristenY;Serack,Bradley;Dantzler,WilliamH;Pannabecker,ThomasL
在髓质内部，肾单位和血管围绕集合管（CD）簇的放射状组织导致两个侧向间质区域和优先的节段间液体和溶质流动。由于下行（DTLs）和上行薄肢（ATL）通过这些区域，它们的跨上皮流体和溶质流量的变量跨上皮溶质梯度和结构间的相互作用的影响。本研究的目标是量化结构与结构的相互作用，以便更好地了解跨上皮水、氯化钠和尿素的区室化和流动以及轴向渗透梯度的产生。为了实现这一目标，我们确定了AQP 1阳性和AQP 1阴性的DTLs和ATL与最近的CD的横向距离，以便测量与团簇间和团簇内横向区域的相互作用以及与间隙节点空间（INS）的相互作用。DTLs表达减少的AQP 1和低跨上皮水渗透性沿着其最深的部分。深AQP 1-null段，预弯曲段，和ATL同样接近CD。预弯段和ATL在其大部分下降和上升过程中分别邻接CD和INS;然而，最长环的远端30%的ATL远离CD，因为它们接近外髓边界，与INS的相互作用最小。这些关系的发生与循环长度无关。最后，我们发现，上升的直小血管分离集群间AQP 1阳性DTLs从下降的直小血管，从而最大限度地减少稀释梯度驱动溶质分泌。我们假设DTLs和ATL以协调的方式进入和退出CD簇，这对于通过最小化NaCl和尿素损失来产生皮质毛细血管溶质梯度是重要的。
In the inner medulla, radial organization of nephrons and blood vessels around collecting duct (CD) clusters leads to two lateral interstitial regions and preferential intersegmental fluid and solute flows. As the descending (DTLs) and ascending thin limbs (ATLs) pass through these regions, their transepithelial fluid and solute flows are influenced by variable transepithelial solute gradients and structure-to-structure interactions. The goal of this study was to quantify structure-to-structure interactions, so as to better understand compartmentation and flows of transepithelial water, NaCl, and urea and generation of the axial osmotic gradient. To accomplish this, we determined lateral distances of AQP1-positive and AQP1-negative DTLs and ATLs from their nearest CDs, so as to gauge interactions with intercluster and intracluster lateral regions and interactions with interstitial nodal spaces (INSs). DTLs express reduced AQP1 and low transepithelial water permeability along their deepest segments. Deep AQP1-null segments, prebend segments, and ATLs lie equally near to CDs. Prebend segments and ATLs abut CDs and INSs throughout much of their descent and ascent, respectively; however, the distal 30% of ATLs of the longest loops lie distant from CDs as they approach the outer medullary boundary and have minimal interaction with INSs. These relationships occur regardless of loop length. Finally, we show that ascending vasa recta separate intercluster AQP1-positive DTLs from descending vasa recta, thereby minimizing dilution of gradients that drive solute secretion. We hypothesize that DTLs and ATLs enter and exit CD clusters in an orchestrated fashion that is important for generation of the corticopapillary solute gradient by minimizing NaCl and urea loss.
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DOI：
10.1152/ajprenal.00068.2008
发表时间：
2008-06
期刊：
American journal of physiology. Renal physiology
影响因子：
--
作者：
T. Pannabecker;Cory Henderson;W. Dantzler
通讯作者：
T. Pannabecker;Cory Henderson;W. Dantzler
DOI：
10.1172/jci116948
发表时间：
1994
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
T. Pallone;J. Work;R. Myers;R. Jamison
通讯作者：
T. Pallone;J. Work;R. Myers;R. Jamison
用于从 1.0 μm 厚的环氧树脂切片上去除树脂的两种快速且简单的方法
影响因子：
2
作者：
M. Maxwell
通讯作者：
M. Maxwell
有利于钠从亨利细环向外移动的浓度梯度的证据。
DOI：
10.1172/jci108633
发表时间：
1977
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
P. Johnston;C. Battilana;F. Lacy;R. Jamison
通讯作者：
R. Jamison
内髓质下降和上升直肠血管的结构：逆流交换的途径。
DOI：
10.1152/ajprenal.00071.2010
发表时间：
2010
期刊：
American journal of physiology. Renal physiology
影响因子：
--
作者：
Yuan,Justin;Pannabecker,ThomasL
通讯作者：
Pannabecker,ThomasL