α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.
α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.
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DOI：
10.4049/jimmunol.1003722
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发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Ulloa L
中科院分区：
文献类型：
--
作者：
Vida G;Peña G;Deitch EA;Ulloa L
Classically, sympathetic and parasympathetic systems act in opposition to maintain the physiological homeostasis. In this article, we report that both systems work together to restrain systemic inflammation in life-threatening conditions such as sepsis. This study indicates that vagus nerve and cholinergic agonists activate the sympathetic noradrenergic splenic nerve to control systemic inflammation. Unlike adrenalectomy, splenectomy and splenic neurectomy prevent the anti-inflammatory potential of both the vagus nerve and cholinergic agonists, and abrogate their potential to induce splenic and plasma norepinephrine. Splenic nerve stimulation mimics vagal and cholinergic induction of norepinephrine and re-establishes neuromodulation in α7 nicotinic acetylcholine receptor (α7nAChR)-deficient animals. Thus, vagus nerve and cholinergic agonists inhibit systemic inflammation by activating the noradrenergic splenic nerve via the α7nAChR nicotinic receptors. α7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation.
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影响因子：
5.4
作者：
Pena, Geber;Cai, Bolin;Liu, Jun;van der Zanden, Esmerij P.;Deitch, Edwin A.;de Jonge, Wouter J.;Ulloa, Luis
通讯作者：
Ulloa, Luis
影响因子：
5.3
作者：
Cai B;Chen F;Ji Y;Kiss L;de Jonge WJ;Conejero-Goldberg C;Szabo C;Deitch EA;Ulloa L
通讯作者：
Ulloa L
DOI：
10.1152/ajpendo.2001.280.2.e378
发表时间：
2001-02-01
影响因子：
5.1
作者：
Benthem, L;Mundinger, TO;Taborsky, GJ
通讯作者：
Taborsky, GJ
DOI：
10.1093/jnen/63.2.138
发表时间：
2004-02-01
影响因子：
3.2
作者：
Del Signore, A;Gotti, C;Paggi, P
通讯作者：
Paggi, P
影响因子：
15.1
作者：
BELLINGER, DL;LORTON, D;FELTEN, DL
通讯作者：
FELTEN, DL