Transient inactivation of the ventral tegmental area selectively disrupts the expression of conditioned place preference for pup- but not cocaine-paired contexts.
Transient inactivation of the ventral tegmental area selectively disrupts the expression of conditioned place preference for pup- but not cocaine-paired contexts.
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DOI：
10.1037/a0017666
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发表时间：
2009-12
影响因子：
1.9
通讯作者：
Morrell, Joan I.
中科院分区：
文献类型：
--
作者：
Seip, Katharine M.;Morrell, Joan I.
腹侧被盖区（VTA）在动机行为中起着重要作用。然而，目前还不清楚完整的腹侧被盖区功能是否是必要的动机行为，以寻求反复配对的自然刺激和/或药理刺激的背景。在本研究中，在两个女性模型中，使用具有强烈激励价值的高度显著的自然或药物刺激诱导条件性位置偏好（CPP）：使产后雌性适应性地将CPP装置中的一种独特环境与年幼的后代（幼鼠）相关联，并将第二种环境与中性刺激相关联，并且处女雌性被条件化以将独特的环境与可卡因（5 mg/kg i. p.）和盐水注射。在CPP测试之前，每只雌性动物接受双侧布比卡因微输注至VTA中，以暂时性抑制该区域;受试者还在生理盐水微输注至VTA后接受测试。产后女性的偏好的小狗配对的背景下被废除VTA失活，但恢复到高控制水平后，盐水微输注。在单独的测试中，腹侧被盖区失活也减少了产后女性的主动舔和小狗检索，表明完整的腹侧被盖区功能是表达小狗CPP和主动小狗导向行为所必需的。Coagulant CPP不受VTA失活的影响。VTA微量输注不影响运动，但布比卡因微量输注到黑质严重受损。我们的结论是，VTA差异参与的条件偏好的表达与小狗，一个突出的自然刺激，和上下文与可卡因配对的上下文。
The ventral tegmental area (VTA) plays a critical role in motivated behavior. However, it remains unclear whether intact VTA function is necessary for motivated behavior to seek contexts repeatedly paired with natural stimuli and/or pharmacological stimuli. In the present study, conditioned place preference (CPP) was induced using highly salient natural or drug stimuli attributed with strong incentive-motivational value in each of two female models: postpartum females were conditioned to associate one unique context in the CPP apparatus with young offspring (pups) and a second context with a neutral stimulus, and virgin females were conditioned to associate unique contexts with cocaine (5mg/kg i.p.) and saline injections. Immediately prior to CPP testing, each female received a microinfusion of bupivacaine bilaterally into the VTA to transiently inactivate the region; subjects were also tested following saline microinfusion into the VTA. Postpartum females’ preference for the pup-paired context was abolished by VTA inactivation but was restored to high control levels following saline microinfusion. In separate tests, VTA inactivation also reduced motivated pup licking and pup retrieval in postpartum females, suggesting that intact VTA function is required for the expression of both pup CPP and motivated pup-directed behaviors. Cocaine CPP remained unaffected by VTA inactivation. Locomotion was not affected by VTA microinfusions but was severely impaired by bupivacaine microinfusions into the substantia nigra. We conclude that the VTA is differentially involved in the expression of conditioned preference for contexts paired with pups, a salient natural stimulus, and contexts paired with cocaine.
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影响因子：
5.3
作者：
Borgland, SL;Malenka, RC;Bonci, A
通讯作者：
Bonci, A
影响因子：
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影响因子：
1.9
作者：
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Fleming, Alison S.
影响因子：
3.7
作者：
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Gerdjikov, TV
影响因子：
3.3
作者：
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