Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications.
Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications.
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小众中的Sertoli细胞 - 圆细胞相互作用:旁分和近二碱分子通信。
DOI:
10.3389/fendo.2022.897062
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发表时间:
2022
影响因子:
5.2
通讯作者:
McBeath, Elena
中科院分区:
文献类型:
--
作者:
Hofmann, Marie-Claude;McBeath, Elena
Male germ cell development depends on multiple biological events that combine epigenetic reprogramming, cell cycle regulation, and cell migration in a spatio-temporal manner. Sertoli cells are a crucial component of the spermatogonial stem cell niche and provide essential growth factors and chemokines to developing germ cells. This review focuses mainly on the activation of master regulators of the niche in Sertoli cells and their targets, as well as on novel molecular mechanisms underlying the regulation of growth and differentiation factors such as GDNF and retinoic acid by NOTCH signaling and other pathways.
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