Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications.

Sertoli Cell-Germ Cell Interactions Within the Niche: Paracrine and Juxtacrine Molecular Communications.
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小众中的Sertoli细胞 - 圆细胞相互作用:旁分和近二碱分子通信。

DOI:
10.3389/fendo.2022.897062
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发表时间:
2022
影响因子:
5.2
通讯作者:
McBeath, Elena
McBeath, Elena
中科院分区:
医学2区
文献类型:
--
作者:
Hofmann, Marie-Claude;McBeath, Elena

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雄性生殖细胞的发育依赖于多种生物学事件,这些事件以时空方式联合收割机了表观遗传重编程、细胞周期调节和细胞迁移。支持细胞是精原干细胞生态位的重要组成部分,为生殖细胞的发育提供必需的生长因子和趋化因子。这篇综述主要集中在支持细胞及其靶点的小生境的主调节因子的激活,以及NOTCH信号传导和其他途径调节生长和分化因子如GDNF和视黄酸的新分子机制。
Male germ cell development depends on multiple biological events that combine epigenetic reprogramming, cell cycle regulation, and cell migration in a spatio-temporal manner. Sertoli cells are a crucial component of the spermatogonial stem cell niche and provide essential growth factors and chemokines to developing germ cells. This review focuses mainly on the activation of master regulators of the niche in Sertoli cells and their targets, as well as on novel molecular mechanisms underlying the regulation of growth and differentiation factors such as GDNF and retinoic acid by NOTCH signaling and other pathways.
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