Does clozapine decrease smoking?
Does clozapine decrease smoking?
复制标题
氯氮平可以减少吸烟吗？
DOI：
10.1016/j.pnpbp.2005.04.031
复制
发表时间：
2005
影响因子：
5.6
通讯作者：
Simpson,GeorgeM
中科院分区：
文献类型：
--
作者：
deLeon,Jose;Diaz,FranciscoJ;Josiassen,RichardC;Cooper,ThomasB;Simpson,GeorgeM
McEhran等人在1999年的研究中，使用了可替宁水平，但效力有限，表明氯氮平治疗可能与轻度吸烟减少有关（特别是当血浆氯氮平水平> 150 ng/ml时）。一些自然主义研究也表明，氯氮平治疗可能与轻度吸烟减少有关。本研究纳入了38名精神分裂症每日吸烟者的双盲氯氮平试验。对5项分析进行了检验，以确定血浆可替宁水平从氟哌啶醇基线显著降低至：（1）关于氯氮平剂量的氯氮平试验结束（100、300或600 mg/天），（2）氯氮平试验结束时达到最高血浆氯氮平水平，（3）氯氮平水平达到150-450 ng/ml范围的氯氮平试验结束时，（4）第一次氯氮平试验结束时，与氯氮平剂量无关，和（5）研究中最后一次氯氮平试验结束时。第一次和直接的剂量分析表明，氯氮平对吸烟没有影响。第二次和第三次分析（试图模仿McEhrman等人的设计[McEhrman，J. P.，弗罗伊登赖希，O.，威尔逊，W.H.，1999.吸烟与精神分裂症患者对氯氮平的治疗反应。精神病学生物学46，125-129.]）也表明氯氮平对吸烟没有显著影响。第四次和第五次分析也是负面的。在我们的氯氮平试验中，五项分析都没有证明氯氮平对吸烟有重大影响。这项研究不能排除在某些受试者中，氯氮平治疗可能与吸烟的小幅减少有关。新的前瞻性纵向研究使用重复可替宁和氯氮平水平，以探讨是否氯氮平可以减少吸烟在一些患者。
McEvoy et al.'s study in 1999, which used cotinine levels but had limited power, suggested that clozapine treatment may be associated with a mild smoking decrease (particularly when plasma clozapine levels are > 150 ng/ml). Some naturalistic studies also suggest that clozapine treatment may be associated with a mild smoking decrease. The present study included 38 schizophrenic daily smokers from a double-blind clozapine trial. Five analyses were tested for significant decreases in plasma cotinine levels from a haloperidol baseline to: (1) the end of clozapine trials regarding clozapine doses (100, 300 or 600 mg/day), (2) the end of the clozapine trial where the highest plasma clozapine level was achieved, (3) the end of the clozapine trial where a clozapine level in the 150–450 ng/ml range was achieved, (4) the end of the first clozapine trial regardless of clozapine dose, and (5) the end of the last clozapine trial in the study. The first and straightforward analysis by dose showed no clozapine effects on smoking. The second and the third analyses (an attempt to mimic the design by McEvoy et al. [McEvoy, J.P., Freudenreich, O., Wilson, W.H., 1999. Smoking and therapeutic response to clozapine in patients with schizophrenia. Biol. Psychiat. 46, 125–129.]) also indicated that there was not a significant effect of clozapine on smoking. The fourth and five analyses were also negative. None of the five analyses in our clozapine trial demonstrated that clozapine had major effects on smoking. This study cannot rule out that in some subjects, clozapine treatment may be associated with a small decrease in smoking. New prospective longitudinal studies using repeated cotinine and clozapine levels are needed to explore whether clozapine may reduce smoking in some patients.
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功效和精度：用于统计功效分析和置信区间的计算机程序
DOI：
--
发表时间：
1997
期刊：
影响因子：
--
作者：
M. Borenstein;H. Rothstein;Jacob Cohen
通讯作者：
Jacob Cohen
影响因子：
--
作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
通讯作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
影响因子：
10.6
作者：
Frankenburg, FR;Zanarini, MC;Centorrino, F
通讯作者：
Centorrino, F
氯氮平对慢性精神分裂症门诊患者吸烟的影响。
影响因子：
5.3
作者：
T. George;M. Sernyak;D. Ziedonis;S. Woods
通讯作者：
S. Woods
DOI：
10.1080/14622200210123581
发表时间：
2002-05-01
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
--
作者：
通讯作者：
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