Anesthesia differentially modulates spontaneous network dynamics by cortical area and layer.
Anesthesia differentially modulates spontaneous network dynamics by cortical area and layer.
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麻醉通过皮质区域和层来差异调节自发网络动力学。
DOI：
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发表时间：
2013
影响因子：
2.5
通讯作者：
Flavio Fröhlich
中科院分区：
文献类型：
--
作者：
K. Sellers;Davis Bennett;A. Hutt;Flavio Fröhlich
麻醉广泛应用于医学和研究中，以实现意识和认知状态的改变。尽管以脑电图空间分辨率测量的麻醉对宏观皮层活动模式的变化已被广泛研究，但麻醉对介观和微观网络动力学的调节仍然知之甚少。为了解决这一知识差距，我们记录了清醒和异氟醚麻醉的雪貂（Mustela putoris Furo）初级视觉皮层（V1）和前额叶皮层（PFC）的自发介观（局部场电位）和微观（多单位活动）网络动态。这种方法允许检查作为皮质区域、皮质层和麻醉深度的函数的活动，其空间和时间分辨率比以前的研究高得多。我们假设初级感觉区和关联皮质区由于其不同的功能作用而表现出不同的麻醉网络调制模式。事实上，我们发现了特定于皮质区域和皮质层的效应。 V1 在麻醉时表现出节律结构的最小变化，但输入层 IV 存在差分调制。相比之下，麻醉极大地改变了 PFC 的光谱功率，使整个皮质层的调制更加均匀。我们的结果表明，麻醉以特定区域和特定层的方式调节自发皮质活动。这些发现为以下方面奠定了基础：1）完善麻醉监测算法，2）重新评估在麻醉动物中进行的大量系统神经科学研究，3）增加我们对跨皮质层和区域的差异动力学的理解。
Anesthesia is widely used in medicine and research to achieve altered states of consciousness and cognition. Whereas changes to macroscopic cortical activity patterns by anesthesia measured at the spatial resolution of electroencephalography have been widely studied, modulation of mesoscopic and microscopic network dynamics by anesthesia remain poorly understood. To address this gap in knowledge, we recorded spontaneous mesoscopic (local field potential) and microscopic (multiunit activity) network dynamics in primary visual cortex (V1) and prefrontal cortex (PFC) of awake and isoflurane anesthetized ferrets (Mustela putoris furo). This approach allowed for examination of activity as a function of cortical area, cortical layer, and anesthetic depth with much higher spatial and temporal resolution than in previous studies. We hypothesized that a primary sensory area and an association cortical area would exhibit different patterns of network modulation by anesthesia due to their different functional roles. Indeed, we found effects specific to cortical area and cortical layer. V1 exhibited minimal changes in rhythmic structure with anesthesia but differential modulation of input layer IV. In contrast, anesthesia profoundly altered spectral power in PFC, with more uniform modulation across cortical layers. Our results demonstrate that anesthesia modulates spontaneous cortical activity in an area- and layer-specific manner. These finding provide the basis for 1) refining anesthesia monitoring algorithms, 2) reevaluating the large number of systems neuroscience studies performed in anesthetized animals, and 3) increasing our understanding of differential dynamics across cortical layers and areas.
影响因子：
33.6
作者：
Wang XJ
通讯作者：
Wang XJ
影响因子：
3.6
作者：
N. Harrison;J. L. Kugler;Mathew V. Jones;Eric P. Greenblatt;D. B. Pritchett
通讯作者：
N. Harrison;J. L. Kugler;Mathew V. Jones;Eric P. Greenblatt;D. B. Pritchett
影响因子：
13.9
作者：
Brown EN;Purdon PL;Van Dort CJ
通讯作者：
Van Dort CJ