General anesthesia and altered states of arousal: a systems neuroscience analysis.
General anesthesia and altered states of arousal: a systems neuroscience analysis.
复制标题
DOI：
10.1146/annurev-neuro-060909-153200
复制
发表时间：
2011
影响因子：
13.9
通讯作者：
Van Dort CJ
中科院分区：
文献类型：
--
作者：
Brown EN;Purdon PL;Van Dort CJ
将患者置于全身麻醉状态对于安全、人道地执行大多数外科手术和许多非外科手术至关重要。麻醉药物如何产生全身麻醉状态被认为是现代医学的一大谜团。由唤醒和/或认知改变引起的无意识可能是全身麻醉最令人着迷的行为状态。我们通过将五类静脉麻醉药的行为和生理特征与这些药物据称起作用的分子靶点和神经回路联系起来，对五类静脉麻醉药引起的唤醒状态改变进行系统神经科学分析。觉醒的改变状态包括镇静-无意识、镇静-镇痛、解离麻醉、药物非快速眼动睡眠和精神安定麻醉。每一种唤醒状态的改变都是麻醉药物作用于中枢神经系统多个目标的结果。我们的分析表明，全身麻醉并不像目前认为的那么神秘。
Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. How anesthetic drugs create the state of general anesthesia is considered a major mystery of modern medicine. Unconsciousness, induced by altered arousal and/or cognition, is perhaps the most fascinating behavioral state of general anesthesia. We perform a systems neuroscience analysis of the altered arousal states induced by five classes of intravenous anesthetics by relating their behavioral and physiological features to the molecular targets and neural circuits at which these drugs are purported to act. The altered states of arousal are sedation-unconsciousness, sedation-analgesia, dissociative anesthesia, pharmaco-logic non-REM sleep, and neuroleptic anesthesia. Each altered arousal state results from the anesthetic drugs acting at multiple targets in the central nervous system. Our analysis shows that general anesthesia is less mysterious than currently believed.
登录
查看更多内容
影响因子：
5.3
作者：
Bai, DL;Pennefather, PS;Orser, BA
通讯作者：
Orser, BA
影响因子：
5.7
作者：
Bieda, Mark C.;Su, Henry;Maclver, M. Bruce
通讯作者：
Maclver, M. Bruce
影响因子：
9.8
作者：
ANGEL, A
通讯作者：
ANGEL, A
DOI：
10.1073/pnas.1011949107
发表时间：
2010-12-07
影响因子：
11.1
作者：
Breshears, Jonathan D.;Roland, Jarod L.;Leuthardt, Eric C.
通讯作者：
Leuthardt, Eric C.
影响因子：
56.9
作者：
Blackstone, E;Morrison, M;Roth, MB
通讯作者：
Roth, MB