Altered engagement of attention and default networks during target detection in schizophrenia.

Altered engagement of attention and default networks during target detection in schizophrenia.
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DOI:
10.1016/j.schres.2010.08.041
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发表时间:
2011-02
影响因子:
4.5
通讯作者:
Duncan, Erica
Duncan, Erica
中科院分区:
医学2区
文献类型:
--
作者:
Hasenkamp, Wendy;James, G. Andrew;Boshoven, William;Duncan, Erica

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最近的研究表明,功能性大脑网络的不适当参与(例如:默认模式)。这项功能性磁共振成像研究在一个简单的目标检测任务中,10名精神分裂症患者和10名健康对照者的显著阴性症状的taskinduced激活和失活。组间比较发现,在这项任务中,不同的注意力网络的招聘,精神分裂症受试者激活背侧注意力系统和控制激活执行网络。此外,精神分裂症患者在任务期间未能使后扣带回区域失活,支持最近关于改变默认模式处理的研究。这些发现支持了精神分裂症患者大规模大脑网络功能失调的理论。
Recent studies have implicated inappropriate engagement of functional brain networks (e.g.: default mode) in schizophrenia. This fMRI study examined taskinduced activations and deactivations in 10 schizophrenia patients with prominent negative symptoms and 10 healthy controls during a simple target detection task. Group comparison revealed recruitment of distinct attentional networks during this task, with schizophrenia subjects activating the dorsal attention system and controls activating the executive network. Further, schizophrenia patients failed to deactivate posterior cingulate regions during the task, supporting recent studies of altered default mode processing. These findings support theories of dysfunctional recruitment of large-scale brain networks in schizophrenia.
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